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Series GSE8690 Query DataSets for GSE8690
Status Public on Jul 31, 2008
Title Microarray analysis identifies distinct subpopulations of arthritic mice deficient for interleukin 1 receptor antagonist
Organism Mus musculus
Experiment type Expression profiling by array
Summary Rheumatoid arthritis (RA) is a heterogeneous disease with clinical and biological polymorphisms. However, little is known about baseline molecular variations among individual RA patients. The purpose of this study was to address this issue using F2 intercross mice generated from arthritis-prone BALB/c and arthritis-resistant DBA/1 mice deficient for interleukin 1 receptor antagonist (Il1rn). Two distinct subpopulations of arthritic mice were identified in the 38 mice studied. One subgroup of diseased mice was characterized by myeloid cell dominant inflammation, whereas the other was mainly associated with increased anti-apoptotic activities of inflammatory cells.
Keywords: disease state analysis
Overall design Thirteen F2 mice, 18 with arthritis and 18 without, were included in this study. Total RNAs were extracted from individual spleens for Affymmetrix mouse genome array analysis. Normalized data were hierarchically clustered to identify subpopulations of arthritic mice.
Contributor(s) Yan J, Jiao Y, Stuart J, Gu W
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Submission date Aug 03, 2007
Last update date Feb 11, 2019
Contact name Jian Yan
Phone 901-448-7830
Organization name University of Tennessee Health Science Center
Department Orthopedics Surgery
Lab Weikuan Gu
Street address 956 Court Ave
City Memphis
State/province TN
ZIP/Postal code 38163
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (36)
GSM213763 ART1
GSM214004 ART3
GSM214094 ART5
BioProject PRJNA101909

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Supplementary file Size Download File type/resource
GSE8690_RAW.tar 130.4 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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