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Series GSE8733 Query DataSets for GSE8733
Status Public on Aug 10, 2007
Title Folate deficiency enhances arsenic effects on ODC mouse skin gene expression
Organism Mus musculus
Experiment type Expression profiling by array
Summary We demonstrate that expression of key markers of keratinocyte differentiation is suppressed by exposure to sodium arsenite. Folate deficiency exacerbates this effect. In addition, cancer-related cell movement genes, and growth and proliferation genes are altered. Several redox-sensitive transcription factors are implicated in mediating these gene expression changes due to arsenic treatment and folate deficiency.
Keywords: gene expression/microarray
 
Overall design K6/ODC mice were maintained on either a folate deficient or folate sufficient diet and exposed to 0, 1, or 10 ppm sodium arsenite in the drinking water for 30 days. Total RNA was isolated from skin samples and gene expression analyzed using Affymetrix Mouse 430 2.0 GeneChips. Data from 24 samples, with four mice in each of the six treatment groups, were analyzed.
 
Contributor(s) Nelson GM, Ahlborn GJ, Delker DA, Kitchin KT, O'Brien T, Chen Y, Kohan MJ, Roop BC, Ward WO, Allen JW
Citation(s) 17928125
Submission date Aug 09, 2007
Last update date Feb 11, 2019
Contact name Gail M Nelson
E-mail(s) nelson.gail@epa.gov
Phone 919-541-3095
Organization name U.S. Environmental Protection Agency
Street address 109 TW Alexander Dr.
City Research Triangle Park
State/province NC
ZIP/Postal code 27711
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (24)
GSM216653 folatesufficientAs0ppm1
GSM216654 folatesufficientAs0ppm2
GSM216655 folatesufficientAs0ppm3
Relations
BioProject PRJNA101993

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8733_RAW.tar 83.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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