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Series GSE87403 Query DataSets for GSE87403
Status Public on Sep 28, 2016
Title The BET bromodomain inhibitor CPI203 improves lenalidomide activity in in vitro and in vivo models of multiple myeloma by synergistic blockade of Ikaros and c-Myc signaling
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Multiple myeloma (MM) cells were treated with the BET inhibitor CPI203 alone and in combination with lenalidomide plus dexamethasone in vitro and in vivo (mouse xenograft).
We used microarrays to uncover the mechanisms underlying CPI-203 activity in MM, alone and in combination with lenalidomide plus dexamethasone (combo).
 
Overall design Global RNA expression was done in three MM cell lines treated in vitro with the BET inhibitor alone or with the combo for 6h.
 
Contributor(s) Diaz T, Pérez-Galán P, Roué G, Fernandez de Larrea C
Citation(s) 28751557
Submission date Sep 27, 2016
Last update date Mar 21, 2019
Contact name Patricia Pérez-Galán
E-mail(s) pperez@clinic.cat
Phone 932275400
Organization name IDIBAPS
Department Hemato-oncology
Street address Centre Esther Koplowitz, Hemato-oncology dept, Rosello 149-153, 2nd floor
City Barcelona
State/province Barcelona
ZIP/Postal code 08036
Country Spain
 
Platforms (1)
GPL13667 [HG-U219] Affymetrix Human Genome U219 Array
Samples (12)
GSM2330241 ARP1_C 6h
GSM2330242 ARP1_CPI 0.01uM
GSM2330243 ARP1_LENA 5uM/Dexa 0.05uM 6h
Relations
BioProject PRJNA344666

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE87403_RAW.tar 27.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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