GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE8756 Query DataSets for GSE8756
Status Public on Apr 14, 2008
Title Dnmt3l-/+ (maternal methylation-deficient) vs normal 8.5dpc embryos
Organism Mus musculus
Experiment type Expression profiling by array
Summary During oogenesis, DNA methyltransferase 3-like (Dnmt3l) is required for the establishment of the maternal germline DNA methylation imprints that in the offspring, govern the parent-of-origin-specific expression of most known imprinted genes (Science 2001, 294:2536-9). Dnmt3l-deficient dams were crossed with wildtype sires to obtain Dnmt3l-/+ embryos that lack maternal methylation imprints. Gene expression was measured in Dnmt3l-/+ and wildtype embryos and is expected to differ for imprinted genes that are under the control of a maternal methylation mark.
Keywords: genetic modification, DNA methylation
Overall design 1 normal control sample/array. 2 biologically replicate Dnmt3l-/+ samples/arrays.
Web link
Contributor(s) Schulz R, Woodfine K, Menheniott T, Bourc'his D, Bestor T, Oakey R
Citation(s) 18398312
Submission date Aug 13, 2007
Last update date Feb 11, 2019
Contact name Reiner Schulz
Organization name King's College London
Department Medical & Molecular Genetics
Lab Epigenetics
Street address 8th floor Guy's Tower
City London
ZIP/Postal code SE1 9RT
Country United Kingdom
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (3)
GSM217367 embryo_normal_8.5dpc_control
GSM217368 embryo_Dnmt3l-/+_8.5dpc_rep1
GSM217369 embryo_Dnmt3l-/+_8.5dpc_rep2
BioProject PRJNA102029

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8756_RAW.tar 12.5 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap