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Series GSE8771 Query DataSets for GSE8771
Status Public on Sep 15, 2007
Title Expression data from hAT1R transgenic and non-transgenic C57BL/6 mouse heart tissue
Organism Mus musculus
Experiment type Expression profiling by array
Summary Excessive Ang II signaling through AT1R is shown to cause pathological hypertrophy. Underlying molecular mechanisms are not yet known and expression studies are not available so far.
To understand hAT1R signaling, cardiac tissue, from C57BL/6 mouse over expressing hAT1R signaling, is subjected to genomic microarray studies. This data compared with the data from healthy, non transgenic C57BL/6 mouse.
Keywords: disease state analysis
Overall design Mouse heart tissues are collected from age matched and gender matched samples. RNA is isolated using commercial kits as per the manufacturer's instructions and subjected to quality checks before experiments. cRNA preparation, pre hybridization, hybridization and post hybridization were carried out Genomics core facility, Case western reserve university. 3 chips for each category were taken for present analysis.
Contributor(s) Kumar VS, Saad Y, Karnik S
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Submission date Aug 14, 2007
Last update date Feb 11, 2019
Contact name Venkata Suresh Kumar surampudi
Phone 216-445-6636
Organization name Lerner Research Institute
Department Molecular Cardiology
Lab Karnik Lab
Street address 9500 Euclid Avenue
City Cleveland
State/province OH
ZIP/Postal code 44195
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM217868 hAT1R tg Replicate1
GSM217869 hAT1R tg Replicate2
GSM217870 hAT1R tg Replicate3
BioProject PRJNA102057

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8771_RAW.tar 21.8 Mb (http)(custom) TAR (of CEL, EXP)
Processed data included within Sample table
Raw data provided as supplementary file

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