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| Status |
Public on Oct 14, 2019 |
| Title |
The profile of long non-coding RNAs in mouse testis and sperm after exposure to cadmium |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
Expression profiling by high throughput sequencing
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| Summary |
Increasing evidences have shown that cadmium could caused male infertility. However, the exhaustive mechanisms have not been elucidated in mammals. Here, the mice testes and sperm RNA were used to investigate lncRNA expression profiles by stranded-specific RNA-seq on the transcriptome levels after exposure to cadmium. More LncRNA expression have been changed than mRNA genes by cadmium. Furthermore, many novel LncRNA were inducible expression, suggesting that LncRNA might be a good candidate for indicating the reproductive toxicity of cadmium. The present study provides a preliminary database for further exploring the mechanisms of reproductive toxicity caused by cadmium in mammalians.
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| Overall design |
LncRNA profiles of mice (3-5 months) were generated by stranded-specific RNA-seq, using Illumina HiSeqTM 4000 with PE100.
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| Contributor(s) |
Zhang X, Gao F |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 14, 2016 |
| Last update date |
Oct 15, 2019 |
| Contact name |
Xiaoning Zhang |
| E-mail(s) |
zhangxiaoning@ncu.edu.cn
|
| Organization name |
Nanchang University
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| Street address |
999 Xuefu R.D., Nanchang
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| City |
Nanchang |
| ZIP/Postal code |
330031 |
| Country |
China |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE88739 |
Dysregulation of long non-coding RNAs in mouse testis and sperm after exposure to cadmium |
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| Relations |
| BioProject |
PRJNA348429 |
| SRA |
SRP091540 |
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