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| Status |
Public on Nov 09, 2017 |
| Title |
Comparison of gene expression profilings between parental A549, OSK-A549-Colony and OSK-A549-SN |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In the present study, we successfully generated lung cancer stem cell (CSC)-like cells by introducing a small set of transcription factors into a lung cancer cell line (OSK-A549-Colony). In addition to properties that are conventionally referred to as CSC properties, the lung induced CSCs exhibited the ability to form lung cancer-like tissues in vitro with vascular cells and mesenchymal stem cells, which showed structures and immunohistological patterns that were similar to human lung cancer tissues.
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| Overall design |
We extracted total RNA from 3 lung cancer cell lines (parental A549), 3 induced lung cancer stem like cells (OSK-A549-Colony) and 3 differentiated non lung cancer stem like cells (OSK-A549-SN) and hybridized them to Agilent gene expression microarrays.
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| Contributor(s) |
Ogawa H |
| Citation(s) |
28951614 |
| Submission date |
Oct 27, 2016 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Michiyo Koyanagi-Aoi |
| E-mail(s) |
mkoyaoi@med.kobe-u.ac.jp
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| Organization name |
Kobe University
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| Street address |
Chuo-ku, Kusunoki-cho 7-5-1
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| City |
Kobe City |
| ZIP/Postal code |
650-0017 |
| Country |
Japan |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA350784 |
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