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| Status |
Public on Apr 30, 2017 |
| Title |
Gene expression analysis of different subtypes of GSCs upon miR-128 overexpression or downregulation and after knockdown of Polycomb components BMI1 and SUZ12 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To analyze the change of global transcriptome landscape among proneural and mesenchymal GSCs, after the transient knockdown of polycomb repressor complex and upon deregulations of miR-128 in different subtypes of GSCs
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| Overall design |
Pateient derived GSCs were classified among Proneural and Mesenchymal subtypes. Stable GSC were prepared with either overexpression or downregulation of miR-128. The polycomb repressor components BMI1 and SUZ12 were downregulated using siRNA.
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| |
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| Contributor(s) |
Rooj AK, Bronisz A, Godlewski J |
| Citation(s) |
28591575, 30875963, 28528698 |
| Submission date |
Nov 03, 2016 |
| Last update date |
Jul 11, 2019 |
| Contact name |
Arun Kumar Rooj |
| E-mail(s) |
arooj@partners.org
|
| Organization name |
Brigham and Women's Hospital
|
| Department |
Neurosurgery
|
| Lab |
Harvey Cushing Neuro-oncology Lab
|
| Street address |
4 Blackfan Circle
|
| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13497 |
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version) |
|
| Samples (33)
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| Relations |
| BioProject |
PRJNA352395 |
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