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Status |
Public on Mar 23, 2018 |
Title |
The effect of new probiotic mixture in DSS (dextran sulphate sodium) – induced colitis mouse model |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
The current study was designed to clarify signalling pathways and assess possible beneficial effect of new probiotic mixture in DSS (dextran sulphate sodium) – induced colitis mouse model. Manipulation of intestinal microbiota with probiotics represents a promising alternative or adjunct therapy in gastrointestinal disorders and inflammation. RNA extracted from the middle part of colon tissue from ~11 weeks female C57BL/6JOlaHsd mouse strain was used for examination of the global gene expression using Affymetrix GeneChip Mouse Gene 2.0 ST microarrays.
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Overall design |
Two factor experimental design: two conditions (Healthy and DSS-induced colitis) and three treatments (None-saline, Probiotic, CsA-cyclosporine A), w/o CsA treatment of healthy animals. 4 biological replicates per condition, 20 mice altogether.
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Contributor(s) |
Juvan P, Košir R, Paveljšek D, Rogelj I |
Citation(s) |
29633647 |
Submission date |
Nov 15, 2016 |
Last update date |
Apr 16, 2018 |
Contact name |
Peter Juvan |
Phone |
+386 1 543 7595
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Organization name |
Faculty of Medicine, University of Ljubljana
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Department |
Institute of Biochemistry
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Lab |
Center for Functional Genomics and Bio-Chips
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Street address |
Zaloska 4
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City |
Ljubljana |
ZIP/Postal code |
SI-1000 |
Country |
Slovenia |
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Platforms (1) |
GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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Samples (20)
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Relations |
BioProject |
PRJNA353599 |