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Series GSE9043 Query DataSets for GSE9043
Status Public on Aug 24, 2011
Title Dap12 microglia
Organism Mus musculus
Experiment type Expression profiling by array
Summary Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is an inherited brain and bone disease. It manifests as dementia and bone fractures. The PLOSL phenotype is caused by loss-of-function mutations in one of the two genes encoding the components of the DAP12/TREM2 receptor complex. The DAP12/TREM2 complex is expressed in cells of the myeloid lineage, including microglia in the central nervous system (CNS). The molecular mechanisms producing the CNS phenotype of PLOSL remain largely unknown. To gain insight into dysfunctional CNS pathways behind PLOSL, we performed genome-wide expression analysis of Dap12 (Tyrobp)-deficient mouse microglial cells.
Keywords: knock-out response
Overall design Transcript profiles of three wild type and three Dap12-deficient primary microglial cultures were analyzed.
Contributor(s) Kiialainen A, Linturi H, Saharinen J, Lanier LL, Kopra O, Peltonen L
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Submission date Sep 14, 2007
Last update date Feb 11, 2019
Contact name Anna Kiialainen
Phone +46186114951
Organization name Uppsala University
Department Deapartment of Medical Sciences
Street address University Hospital, Entrance 70
City Uppsala
ZIP/Postal code 75185
Country Sweden
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM229790 Dap12-ko microglia 2_8
GSM229791 Dap12-ko microglia 3_11
GSM229792 Dap12-wt microglia 4_5
This SubSeries is part of SuperSeries:
GSE9083 Genome-wide expression analysis of Dap12 (Tyrobp)-deficient mouse brain and microglial cells
BioProject PRJNA105315

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE9043_RAW.tar 22.9 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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