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Series GSE9061 Query DataSets for GSE9061
Status Public on Aug 24, 2011
Title Dap12-deficient mouse brain (1 month)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is an inherited brain and bone disease. It manifests as dementia and bone fractures. The PLOSL phenotype is caused by loss-of-function mutations in one of the two genes encoding the components of the DAP12/TREM2 receptor complex. The DAP12/TREM2 complex is expressed in cells of the myeloid lineage, including microglia in the central nervous system (CNS). The molecular mechanisms producing the CNS phenotype of PLOSL remain largely unknown. To gain insight into dysfunctional CNS pathways behind PLOSL, we performed genome-wide expression analysis of Dap12 (Tyrobp)-deficient mouse brain. In Dap12-deficient mice, we observed alterations in several pathways involved in synaptic function. In agreement with the myelin loss in PLOSL patients, we also saw changes in transcript levels of genes encoding myelin components.
Keywords: knockout response
Overall design Transcript profiles of the midbrain (diencephalon and basal ganglia) of three Dap12-knockout and three heterozygous mice were analyzed.
Contributor(s) Kiialainen A, Linturi H, Saharinen J, Lanier LL, Kopra O, Peltonen L
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Submission date Sep 17, 2007
Last update date Feb 11, 2019
Contact name Anna Kiialainen
Phone +46186114951
Organization name Uppsala University
Department Deapartment of Medical Sciences
Street address University Hospital, Entrance 70
City Uppsala
ZIP/Postal code 75185
Country Sweden
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM229976 Dap12-ko 68
GSM229977 Dap12-ko 67
GSM229979 Dap12-het 75
This SubSeries is part of SuperSeries:
GSE9083 Genome-wide expression analysis of Dap12 (Tyrobp)-deficient mouse brain and microglial cells
BioProject PRJNA105321

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE9061_RAW.tar 99.6 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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