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| Status |
Public on Dec 01, 2016 |
| Title |
Expression data of multi regional colorectal carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed, from which we inferred the evolutionary history of the tumors. First, clonally shared alterations appeared, in which C>T transitions at CpG site and CpG island hypermethylation were relatively enriched. Correlation between mutation counts and patients’ ages suggests that the early-acquired alterations resulted from aging. In the late phase, a parental clone was branched into numerous subclones. Known driver alterations were observed frequently in the early-acquired alterations, but rarely in the late-acquired alterations. Consistently, our computational simulation of the branching evolution suggests that extensive intratumor heterogeneity could be generated by neutral evolution. Collectively, we propose a new model of colorectal cancer evolution, which is useful for understanding and confronting this heterogeneous disease.
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| Overall design |
We isolated total RNA from geographically separated samples of one of eight series (case3) of colorectal carcinoma and matched normal mucosa and hybridised to the Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray
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| Contributor(s) |
Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y |
| Citation(s) |
28542232 |
| Submission date |
Nov 30, 2016 |
| Last update date |
Sep 02, 2019 |
| Contact name |
RYUTARO UCHI |
| Organization name |
KYUSHUUNIVERSItY
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| Street address |
MAIDASHI3-1-1
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| City |
FUKUOKA |
| State/province |
FUKUOKA |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (22)
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| This SubSeries is part of SuperSeries: |
| GSE90709 |
Methylation, expression, and SNP data of multi regional colorectal carcinoma |
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| Relations |
| BioProject |
PRJNA355559 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE90708_RAW.tar |
67.1 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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