|
| Status |
Public on Dec 10, 2008 |
| Title |
Estrogen-modulated gene expression in c-kit+ stem cells and CD44+ stromal cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The recent interest in the role of bone marrow derived endothelial progenitor cells in the benefits of estrogen on cardiovascular health brought us to evaluate if estrogen could affect cardiac repair more broadly by regulating biological processes involved in the functional organization of the bone marrow stem cell niche.
To assess such possibility, we evaluated gene expression profiles of bone marrow c-kit+ stem cells and CD44+ stromal cells, derived from primary whole bone marrow cultured system, after exposure to a physiological concentration of 17β-estradiol (17βE).
Keywords: estrogen treatment response
|
| |
|
| Overall design |
6 samples per cell type (c-kit+ stem cells or CD44+ stromal cells) were analysed. Of these, triplicates of 17βE treated and corresponding control non-treated cells are included.
|
| |
|
| Contributor(s) |
Lemieux C, Cloutier I, Tanguay J |
| Citation(s) |
19006456 |
| Submission date |
Sep 19, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Caroline Lemieux |
| Phone |
514-376-3330 2135
|
| Organization name |
Institut de Cardiologie de Montréal
|
| Department |
Centre de recherche
|
| Lab |
Laboratoire de Cardiologie Interventionnelle Expérimentale
|
| Street address |
5000, Bélanger Est
|
| City |
Montréal |
| State/province |
Québec |
| ZIP/Postal code |
J4N 1P9 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (12)
|
| GSM230331 |
CD44+ stromal cells_control_replicate 1 |
| GSM230332 |
c-kit+ stem cells_control_replicate 1 |
| GSM230333 |
CD44+ stromal cells_17βE_replicate 1 |
| GSM230334 |
c-kit+ stem cells_17βE_replicate 1 |
| GSM230335 |
CD44+ stromal cells_control_replicate 2 |
| GSM230336 |
c-kit+ stem cells_control_replicate 2 |
| GSM230337 |
CD44+ stromal cells_17βE_replicate 2 |
| GSM230338 |
c-kit+ stem cells_17βE_replicate 2 |
| GSM230339 |
CD44+ stromal cells_control_replicate 3 |
| GSM230340 |
CD44+ stromal cells_17βE_replicate 3 |
| GSM230341 |
c-kit+ stem cells_17βE_replicate 3 |
| GSM230342 |
c-kit+ stem cells_control_replicate 3 |
|
| Relations |
| BioProject |
PRJNA102621 |
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