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Series GSE9184 Query DataSets for GSE9184
Status Public on Sep 28, 2007
Title Expression profile from anthrax edema toxin (ET) treated murine bone marrow derived macrophages (BMDM)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Bacillus anthracis, the causative agent of anthrax, secretes three toxin proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA is a transporter of LF and EF into host cells by receptor-mediated endocytosis. LF is a metalloprotease that cleaves mitogen-activated protein kinase (MAPK) kinases (MKK), while EF is an adenylate cyclase, which converts ATP to cAMP.
We used microarrays to decipher the specific gene regulation in edema toxin (ET), the complex of EF and PA, treated mouse bone marrow derived macrophages.
Keywords: Time course
 
Overall design BMDM were treated with 1 mg/ml of ET and the RNAs were purified at 0, 2, and 4h after toxin treatment.
 
Contributor(s) Park JM, Kim C
Citation(s) 18427110
Submission date Sep 27, 2007
Last update date Feb 11, 2019
Contact name Chun Kim
E-mail(s) chun.kim@cbrc2.mgh.harvard.edu
Phone 617-726-4456
Fax 617-726-4453
Organization name Massachusetts General Hospital
Department Cutaneous Biology Research Center
Street address Bldg 149, 13th Street
City Charlestown
State/province MA
ZIP/Postal code 02129
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (3)
GSM232005 BMDM at ET 0h
GSM232006 BMDM at ET 2h
GSM232007 BMDM at ET 4h
Relations
BioProject PRJNA102751

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE9184_RAW.tar 12.6 Mb (http)(custom) TAR (of CEL, CHP, EXP)
Raw data provided as supplementary file
Processed data included within Sample table

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