|
| Status |
Public on Dec 04, 2017 |
| Title |
In vitro modelling of Hypoplastic Left Heart Syndrome (HLHS) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We reprogrammed fibroblasts from 5 HLHS patients and 2 controls into iPSCs and differentiated into cardiomyocytes. By comparison of HLHS and control groups we uncovered the developmental, structural and functional defects of HLHS cells. Through high through-put screening, the underlying molecular mechnisms of HLHS ontology was explored.
|
| |
|
| Overall design |
Cardiomyocyte mRNA profiles of normal control and HLHS samples were generated by deep sequencing, in duplicate, using Illumina HiSeq4000.
|
| |
|
| Contributor(s) |
Lako M, Armstrong L, Yang C |
| Citation(s) |
28521042 |
| Submission date |
Dec 15, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Majlinda Lako |
| E-mail(s) |
majlinda.lako@ncl.ac.uk
|
| Organization name |
Newcastle University
|
| Street address |
Central Parkway
|
| City |
Newcastle upon Tyne |
| ZIP/Postal code |
NE1 3BZ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (3) |
|
| Relations |
| BioProject |
PRJNA357603 |
| SRA |
SRP095190 |
