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| Status |
Public on May 29, 2018 |
| Title |
Genome-wide maps of chromatin state in epiblast stem cells and nodal inhibited ebiblast stem cells |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We reported H3K4me3, H3K27ac and H3K27me3 histone modification in EpiSCs and Nodal inhibited EpiSCs(EpiSCS/F). Using ChIP sequencing, we demonstrate that the active modification of H3K4me3 and H3K27ac level are higher in EpiSCS/F, suggesting EpiSCsS/F were in an active chromatin state. Interestingly, H3K27me3, the supressive modification enriched more in EpiSCS/F down regulated genes, suggesting H3K27me3 plays pivital roles in regulating gene expression.
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| Overall design |
Examination of 3 different histone modifications in 2 cell types
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| |
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| Contributor(s) |
Liu C, Yang X, He Z |
| Citation(s) |
30008328 |
| Submission date |
Dec 20, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Naihe Jing |
| E-mail(s) |
njing@sibcb.ac.cn
|
| Organization name |
Shanghai Institute of Biochemistry and Cell Biology
|
| Street address |
Yue Yang Road 320
|
| City |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
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| Platforms (1) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE92635 |
Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells |
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| Relations |
| BioProject |
PRJNA358284 |
| SRA |
SRP095472 |
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