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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 23, 2017 |
| Title |
Gene expression analysis of PiZ mouse livers |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Transgenic PiZ mice have been genetically engineered to express ATZ and have been a valuable experimental model for studing liver disease associated with AAT deficiency. ATZ accumulates in these mice within the ER of hepatocytes in a nearly identical manner to livers of affected patients. To investigate the pathogenesis of liver damage induced by ATZ, we performed gene expression analysis in livers of 6-week-old PiZ mice and strain-, age-, and gender-matched wild-type mouse controls. All samples were processed on Affymetrix Mouse 430A 2.0 arrays using GeneChip 3’-IVT Plus and Hybridization Wash and Stain kits by means of Affymetrix’s standard protocols. The analysis indicated that most genes upregulated in PiZ livers were associated with response to unfolded proteins, ER nuclear signaling pathway, and response to protein stimulus.
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| Overall design |
Gene expression analysis of 6 week-old wild-type (WT) and PiZ mouse livers
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| Contributor(s) |
Pastore N, Brunetti-Pierri N |
| Citation(s) |
28073160 |
| Submission date |
Jan 04, 2017 |
| Last update date |
May 04, 2018 |
| Contact name |
Annamaria Carissimo |
| E-mail(s) |
carissimo@tigem.it
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| Organization name |
Tigem
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| Street address |
via Castellino
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| City |
Napoli |
| ZIP/Postal code |
80131 |
| Country |
Italy |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA360080 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE93115_RAW.tar |
11.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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