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Series GSE9332 Query DataSets for GSE9332
Status Public on Oct 18, 2007
Title Study of Leukotriene B4 (LTB4) effect on primary human monocytes transcription profile
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation, implicated in numerous diseases including atherosclerosis. We have used primary human monocytes, which express both receptors, to analyze transcriptional responses to LTB4. Comparisons were made between LTB4- and vehicle-treated samples at the same time point. The analysis showed that expression of 72 genes was upregulated at least two-fold at two time points. These genes include multiple chemokines as well as some genes with unknown function.
Keywords: time course
Overall design Cells were stimulated with LTB4 for various times. For each time point, there is one treated sample and one vehicle control. After isolation, each RNA sample is hybridized to duplicate CodeLink chips.
Contributor(s) Sun B, Huang J, Dai H, Xue X, Bittner A, Karlsson L, Fourie AM
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Submission date Oct 15, 2007
Last update date Oct 28, 2014
Contact name Heng Dai
Phone 858-784-3294
Organization name Johnson & Johnson PRD
Department Bioinformatics
Street address 3210 Merryfield Row
City San Diego
State/province CA
ZIP/Postal code 92121
Country USA
Platforms (1)
GPL2895 GE Healthcare/Amersham Biosciences CodeLink Human Whole Genome Bioarray
Samples (9)
GSM237625 Monocyte_Control_0H
GSM237626 Monocyte_LTB4_1H
GSM237627 Monocyte_NoStimulation_1H
BioProject PRJNA103009

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Supplementary data files not provided
Raw data included within Sample table
Processed data included within Sample table

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