NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE93330 Query DataSets for GSE93330
Status Public on Jan 10, 2017
Title Novel Non-catalytic Substrate-selective p38α-specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-inflammatory Activity
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We developed a novel substrate-selective inhibitor of p38 MAPK, UM101, and compared its effects on TNF-induced gene expression by human lung microvascular endothelial cells (HMVECLs) with the prototypical p38 catalytic inhibitor, SB203580
 
Overall design HMVECLs were pretreated with DMSO (vehicle), UM101, or SB203580, then stimulated with TNF for 3h. Total RNA from treated cells and untreated control HMVECLs was isolated, poly(A) mRNA enriched and sequenced using the Illumina HiSeq platform.
 
Contributor(s) Hasday JD
Citation(s) 28298524
Submission date Jan 09, 2017
Last update date Jun 19, 2019
Contact name Theresa K Hodges
E-mail(s) thodges@som.umaryland.edu
Organization name University of Maryland Baltimore
Department Institute for Genome Sciences
Street address 801 W. Baltimore Street
City Baltimore
State/province MD
ZIP/Postal code 21201
Country USA
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (12)
GSM2451435 Control_1
GSM2451436 Control_2
GSM2451437 Control_3
Relations
BioProject PRJNA360618
SRA SRP096339

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93330_RAW.tar 4.5 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap