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| Status |
Public on Jun 23, 2021 |
| Title |
Transcriptome comparison of balding and non-balding dermal papilla aggregates from NHEK co-culturing |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Androgenetic alopecia (AGA, male patterned baldness) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. The keratinocytes-surrounded spheroid dermal papilla (DP) at the base of the hair follicle is essential in hair morphogenesis and cycling. With the aim of elucidating genes involved in AGA pathogenesis, we co-cultured immortalised balding and non-balding human DP cells (DPC) derived from male AGA patients with epidermal keratinocyte (NHEK) using multi-interfacial polyelectrolyte complexation (MIPC) technique, and compared gene expression using RNA-seq between isolated balding and non-balding DP aggregates.
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| Overall design |
Examination of transcriptome difference between isolated balding and non-balding dermal papilla cell aggregates, technical triplicate.
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| Contributor(s) |
Hillmer AM |
| Citation missing |
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| Submission date |
Jan 18, 2017 |
| Last update date |
Jun 23, 2021 |
| Contact name |
Axel HILLMER |
| E-mail(s) |
ahillmer@uni-koeln.de
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| Organization name |
University of Cologne
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| Department |
Institute of Pathology
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| Street address |
Kerpener Str. 62
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| City |
Cologne |
| ZIP/Postal code |
50937 |
| Country |
Germany |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA362329 |
| SRA |
SRP096965 |
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