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| Status |
Public on Jul 24, 2017 |
| Title |
Characterization of three Epithelial Ovarian Cancer cell lines resistant to cisplatin (mRNA). |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Epithelial ovarian cancer (EOC) represents the gynecologic cancer with the highest mortality rate. Despite a high initial response to chemotherapy, the majority of patients with advanced EOC relapses and subsequently develops chemoresistance that results in treatment failure and death of the patient. AIM: we have generated an isogenic model of PT-resistance in a panel of 3 EOC cell lines. Gene Expression Profile (GEP) was used to identify new molecular pathawy that regulate chemoresistance.
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| Overall design |
GEP experiments were performed in 3 Epithelian Ovarian Cancer cell lines Platinum-resistant vs their parental, with Agilent platform. Bioinformatics analyses were performed by Gene Springs
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| Contributor(s) |
Sonego M, Pellizzari I, Bomben R, Baldassarre G |
| Citation(s) |
28769043 |
| Submission date |
Jan 18, 2017 |
| Last update date |
Aug 25, 2019 |
| Contact name |
Riccardo Bomben |
| E-mail(s) |
rbomben@cro.it
|
| Phone |
+39 0434 659718
|
| Organization name |
CRO Aviano
|
| Department |
D-RT
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| Lab |
Clinical and Experimental Onco Hematology Unit
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| Street address |
Via Franco Gallini 2
|
| City |
Aviano |
| ZIP/Postal code |
33080 |
| Country |
Italy |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE93795 |
Characterization of three Epithelial Ovarian Cancer cell lines resistant to cisplatin. |
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| Relations |
| BioProject |
PRJNA362360 |
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