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Series GSE93869 Query DataSets for GSE93869
Status Public on Jan 22, 2018
Title Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
Organism Mus musculus
Experiment type Expression profiling by array
Summary In our previous study, mice with pulmonary fibrosis induced by a bleomycin insult in the context of short telomeres develop pulmonary fibrosis. By using AAV9 vectors carrying the telomerase Tert gene to treat those mice, we explore the possibility of telomerase gene therapy as a possible treatment for IPF patients carrying short telomeres. To further understand gene expression changes undergoing in ATII cells upon telomerase activation, we isolated ATII cells from pulmonary fibrosis Tert-treated and empty vector-treated lungs at 1 week after AAV9 inoculation by FACS.
 
Overall design Mice with pulmonary fibrosis were treated with either AAV9-Tert or empty vector and were sacrificed 1 week post-virus inoculation. ATII cells were sorted by FACS from mouse lungs of both groups AAV9-Tert and AAV9-empty vector.
 
Contributor(s) Povedano JM, Martinez P, Gomez-Lopez G, Blasco MA
Citation(s) 29378675
Submission date Jan 19, 2017
Last update date Jan 31, 2018
Contact name Gonzalo Gomez-Lopez
Organization name CNIO
Department Structural Biology
Lab Bioinformatics
Street address Calle Melchor Fdez Almagro 3
City Madrid
State/province Madrid
ZIP/Postal code 28029
Country Spain
 
Platforms (1)
GPL21163 Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version]
Samples (6)
GSM2464309 ATII_Empty1
GSM2464310 ATII_Empty2
GSM2464311 ATII_Empty3
Relations
BioProject PRJNA362624

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93869_RAW.tar 30.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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