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| Status |
Public on Dec 31, 2017 |
| Title |
Cardamonin attenuate colon tumorigenesis by inhibiting cell proliferation and inflammation |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
The effect of Cardamonin was checked on Azoxymethane (AOM) induced colon cancer in C57Bl/6 mice.
C57Bl/6 were given single weekly injection of AOM (10mg/kg B.wt) for six weeks. Cardamonin treatment (10mg/Kg B.wt, p.o) was started simulatenously for one group. For the second group it was started after 16 of first AOM injection. The study was terminated at 30 weeks. The RNA was ioslated uisng mirVANA kit from each samples followed miRNA analysis uisng affymetrix gene chip miRNA array 4.0
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| Overall design |
14 samples were analysed. The differential expression of miRNAs between groups were analysed.
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| Contributor(s) |
James S, Aparna JS, Paul AS, Manendra BL, Sabira M, Girijadevi R, Harikumar KB |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 23, 2017 |
| Last update date |
Jan 01, 2018 |
| Contact name |
Dr. Harikumar K B |
| E-mail(s) |
harikumar@rgcb.res.in
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| Phone |
+91-471-2529-596
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| Organization name |
Rajiv Gandhi centre for Biotechnology
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| Department |
Cancer Research Program
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| Lab |
CRP-7
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| Street address |
Poojappura
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| City |
Thycaud |
| State/province |
Kerala |
| ZIP/Postal code |
695 014 |
| Country |
India |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (14)
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| GSM2465298 |
Colon, AOM treated, Vehicle control, biological rep.1 |
| GSM2465299 |
Colon, AOM treated, Vehicle control, biological rep.2 |
| GSM2465300 |
Colon, AOM treated, Vehicle control, biological rep.3 |
| GSM2465301 |
Colon, AOM treated, Cardamonin simultaneous treatment, biol.rep.1 |
| GSM2465302 |
Colon, AOM treated, Cardamonin simultaneous treatment, biol.rep.2 |
| GSM2465303 |
Colon, AOM treated, Cardamonin simultaneous treatment, biol.rep.3 |
| GSM2465304 |
Colon, AOM treated, Cardamonin simultaneous treatment, biol.rep.4 |
| GSM2465305 |
Colon, AOM treated, Cardamonin treatment after tumor formation, biol.rep.1 |
| GSM2465306 |
Colon, AOM treated, Cardamonin treatment after tumor formation, biol.rep.2 |
| GSM2465307 |
Colon, AOM treated, Cardamonin treatment after tumor formation, biol.rep.3 |
| GSM2465308 |
Colon, AOM treated, Cardamonin treatment after tumor formation, biol.rep.4 |
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| Relations |
| BioProject |
PRJNA362862 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE93936_RAW.tar |
11.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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