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| Status |
Public on Oct 12, 2017 |
| Title |
The transcriptome of estrogen-independent mammary growth induced by dietary conjugated linoleic acid |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequencing confirmed that both E and CLA increased the expression of genes involved in proliferation and cell cycle progression. The transcriptome of the mammary glands from E-treated mice was characterized by canonical E-induced genes including Pgr and Areg, whereas CLA differentially regulated the expression of genes implicated in inflammation – a finding in-line with perturbation of the mammary stroma stimulated by CLA.
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| |
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| Overall design |
A total of 8 groups (Control_60h, Estrogen_60h, Control_84h, Estrogen_84h, Control 108h, CLA_108h, Control_132h, CLA_132h) were analyzed with 5 biological replicates per group for a total of 40 samples.
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| |
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| Contributor(s) |
Berryhill GE, Hovey RC |
| Citation(s) |
28938404 |
| Submission date |
Jan 26, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Grace E Berryhill |
| E-mail(s) |
geberryhill@ucdavis.edu
|
| Phone |
5307524970
|
| Organization name |
University of California, Davis
|
| Department |
Animal Science
|
| Lab |
Russell C Hovey Laboratory
|
| Street address |
One Shields Avenue
|
| City |
Davis |
| State/province |
CA |
| ZIP/Postal code |
95616 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (40)
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| Relations |
| BioProject |
PRJNA368980 |
| SRA |
SRP097921 |
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