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| Status |
Public on Feb 01, 2017 |
| Title |
Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis |
| Platform organisms |
Homo sapiens; synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
Neutrophils in children with the polyarticular form of juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These abnormalities include re-ordering of miRNA-RNA expression networks. In this study, we sought to determine the effects of therapy on miRNA-RNA networks in polyarticular JIA. We studied children with active JIA disease on therapy (ADM), children with inactive disease also on therapy (ID), and children with clinical remission on medication (CRM) using exon and miRNA microarrays and compared results to findings from healthy control (HC) children. We found substantial re-ordering of miRNA-RNA networks after the initiation of therapy. Each disease state was associated with a distinct transcriptional profile.
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| Overall design |
Total RNA and miRNA were extracted from isolated neutrophils from patients with JIA and healthy control children.
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| Contributor(s) |
Jiang K, Hu Z, Frank MB, Chen Y, Jarvis JN |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 31, 2017 |
| Last update date |
May 02, 2017 |
| Contact name |
kaiyu Jiang |
| Organization name |
University at Buffalo
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| Department |
Pediatrics
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| Street address |
875 Ellicott Street
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| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14203 |
| Country |
USA |
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| Platforms (2) |
| GPL5188 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
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| Samples (145)
|
| GSM2473817 |
Neutrophils, Patient, JIA, ADM, Biological replicate 1 [RNA] |
| GSM2473818 |
Neutrophils, Patient, JIA, ADM, Biological replicate 2 [RNA] |
| GSM2473819 |
Neutrophils, Patient, JIA, ADM, Biological replicate 3 [RNA] |
| GSM2473820 |
Neutrophils, Patient, JIA, ADM, Biological replicate 4 [RNA] |
| GSM2473821 |
Neutrophils, Patient, JIA, ADM, Biological replicate 5 [RNA] |
| GSM2473822 |
Neutrophils, Patient, JIA, ADM, Biological replicate 6 [RNA] |
| GSM2473823 |
Neutrophils, Patient, JIA, ADM, Biological replicate 7 [RNA] |
| GSM2473824 |
Neutrophils, Patient, JIA, ADM, Biological replicate 8 [RNA] |
| GSM2473825 |
Neutrophils, Patient, JIA, ADM, Biological replicate 9 [RNA] |
| GSM2473826 |
Neutrophils, Patient, JIA, ADM, Biological replicate 10 [RNA] |
| GSM2473827 |
Neutrophils, Patient, JIA, ADM, Biological replicate 11 [RNA] |
| GSM2473828 |
Neutrophils, Patient, JIA, ADM, Biological replicate 12 [RNA] |
| GSM2473829 |
Neutrophils, Patient, JIA, ADM, Biological replicate 13 [RNA] |
| GSM2473830 |
Neutrophils, Patient, JIA, ADM, Biological replicate 14 [RNA] |
| GSM2473831 |
Neutrophils, Patient, JIA, ADM, Biological replicate 15 [RNA] |
| GSM2473832 |
Neutrophils, Patient, JIA, ADM, Biological replicate 16 [RNA] |
| GSM2473833 |
Neutrophils, Patient, JIA, ADM, Biological replicate 17 [RNA] |
| GSM2473834 |
Neutrophils, Patient, JIA, ADM, Biological replicate 18 [RNA] |
| GSM2473835 |
Neutrophils, Patient, JIA, ADM, Biological replicate 19 [RNA] |
| GSM2473836 |
Neutrophils, Patient, JIA, ADM, Biological replicate 20 [RNA] |
| GSM2473837 |
Neutrophils, Patient, JIA, ADM, Biological replicate 21 [RNA] |
| GSM2473838 |
Neutrophils, Patient, JIA, ADM, Biological replicate 22 [RNA] |
| GSM2473839 |
Neutrophils, Patient, JIA, ADM, Biological replicate 23 [RNA] |
| GSM2473840 |
Neutrophils, Patient, JIA, ADM, Biological replicate 24 [RNA] |
| GSM2473841 |
Neutrophils, Patient, JIA, ADM, Biological replicate 25 [RNA] |
| GSM2473842 |
Neutrophils, Patient, JIA, ADM, Biological replicate 26 [RNA] |
| GSM2473843 |
Neutrophils, Patient, JIA, CRM, Biological replicate 1 [RNA] |
| GSM2473844 |
Neutrophils, Patient, JIA, CRM, Biological replicate 2 [RNA] |
| GSM2473845 |
Neutrophils, Patient, JIA, CRM, Biological replicate 3 [RNA] |
| GSM2473846 |
Neutrophils, Patient, JIA, CRM, Biological replicate 4 [RNA] |
| GSM2473847 |
Neutrophils, Patient, JIA, CRM, Biological replicate 5 [RNA] |
| GSM2473848 |
Neutrophils, Patient, JIA, CRM, Biological replicate 6 [RNA] |
| GSM2473849 |
Neutrophils, Patient, JIA, CRM, Biological replicate 7 [RNA] |
| GSM2473850 |
Neutrophils, Patient, JIA, CRM, Biological replicate 8 [RNA] |
| GSM2473851 |
Neutrophils, Patient, JIA, CRM, Biological replicate 9 [RNA] |
| GSM2473852 |
Neutrophils, Patient, JIA, CRM, Biological replicate 10 [RNA] |
| GSM2473853 |
Neutrophils, Patient, JIA, CRM, Biological replicate 11 [RNA] |
| GSM2473854 |
Neutrophils, Patient, JIA, CRM, Biological replicate 12 [RNA] |
| GSM2473855 |
Neutrophils, Patient, JIA, CRM, Biological replicate 13 [RNA] |
| GSM2473856 |
Neutrophils, Patient, JIA, CRM, Biological replicate 14 [RNA] |
| GSM2473857 |
Neutrophils, Patient, JIA, CRM, Biological replicate 15 [RNA] |
| GSM2473859 |
Neutrophils, Patient, JIA, CRM, Biological replicate 16 [RNA] |
| GSM2473860 |
Neutrophils, Patient, JIA, CRM, Biological replicate 17 [RNA] |
| GSM2473861 |
Neutrophils, Patient, JIA, CRM, Biological replicate 18 [RNA] |
| GSM2473862 |
Neutrophils, Patient, JIA, CRM, Biological replicate 19 [RNA] |
| GSM2473863 |
Neutrophils, Patient, JIA, CRM, Biological replicate 20 [RNA] |
| GSM2473864 |
Neutrophils, Patient, JIA, CRM, Biological replicate 21 [RNA] |
| GSM2473865 |
Neutrophils, Patient, JIA, CRM, Biological replicate 22 [RNA] |
| GSM2473866 |
Neutrophils, Patient, JIA, CRM, Biological replicate 23 [RNA] |
| GSM2473867 |
Neutrophils, Patient, JIA, CRM, Biological replicate 24 [RNA] |
| GSM2473868 |
Neutrophils, Patient, JIA, CRM, Biological replicate 25 [RNA] |
| GSM2473869 |
Neutrophils, Patient, JIA, CRM, Biological replicate 26 [RNA] |
| GSM2473870 |
Neutrophils, Patient, JIA, CRM, Biological replicate 27 [RNA] |
| GSM2473871 |
Neutrophils, Patient, JIA, CRM, Biological replicate 28 [RNA] |
| GSM2473872 |
Neutrophils, Patient, JIA, ID, Biological replicate 1 [RNA] |
| GSM2473873 |
Neutrophils, Patient, JIA, ID, Biological replicate 2 [RNA] |
| GSM2473874 |
Neutrophils, Patient, JIA, ID, Biological replicate 3 [RNA] |
| GSM2473875 |
Neutrophils, Patient, JIA, ID, Biological replicate 4 [RNA] |
| GSM2473876 |
Neutrophils, Patient, JIA, ID, Biological replicate 5 [RNA] |
| GSM2473877 |
Neutrophils, Patient, JIA, ID, Biological replicate 6 [RNA] |
| GSM2473878 |
Neutrophils, Patient, JIA, ID, Biological replicate 7 [RNA] |
| GSM2473879 |
Neutrophils, Patient, JIA, ID, Biological replicate 8 [RNA] |
| GSM2473880 |
Neutrophils, Patient, JIA, ID, Biological replicate 9 [RNA] |
| GSM2473881 |
Neutrophils, Patient, JIA, ID, Biological replicate 10 [RNA] |
| GSM2473882 |
Neutrophils, Patient, JIA, ID, Biological replicate 11 [RNA] |
| GSM2473883 |
Neutrophils, Patient, JIA, ID, Biological replicate 12 [RNA] |
| GSM2473884 |
Neutrophils, Patient, JIA, ID, Biological replicate 13 [RNA] |
| GSM2473885 |
Neutrophils, Patient, JIA, ID, Biological replicate 14 [RNA] |
| GSM2473886 |
Neutrophils, Patient, JIA, ADM, Biological replicate 1 [miRNA] |
| GSM2473887 |
Neutrophils, Patient, JIA, ADM, Biological replicate 2 [miRNA] |
| GSM2473888 |
Neutrophils, Patient, JIA, ADM, Biological replicate 3 [miRNA] |
| GSM2473889 |
Neutrophils, Patient, JIA, ADM, Biological replicate 4 [miRNA] |
| GSM2473890 |
Neutrophils, Patient, JIA, ADM, Biological replicate 5 [miRNA] |
| GSM2473891 |
Neutrophils, Patient, JIA, ADM, Biological replicate 6 [miRNA] |
| GSM2473892 |
Neutrophils, Patient, JIA, ADM, Biological replicate 7 [miRNA] |
| GSM2473893 |
Neutrophils, Patient, JIA, ADM, Biological replicate 8 [miRNA] |
| GSM2473894 |
Neutrophils, Patient, JIA, ADM, Biological replicate 9 [miRNA] |
| GSM2473895 |
Neutrophils, Patient, JIA, ADM, Biological replicate 10 [miRNA] |
| GSM2473896 |
Neutrophils, Patient, JIA, ADM, Biological replicate 11 [miRNA] |
| GSM2473897 |
Neutrophils, Patient, JIA, ADM, Biological replicate 12 [miRNA] |
| GSM2473898 |
Neutrophils, Patient, JIA, ADM, Biological replicate 13 [miRNA] |
| GSM2473899 |
Neutrophils, Patient, JIA, ADM, Biological replicate 14 [miRNA] |
| GSM2473900 |
Neutrophils, Patient, JIA, ADM, Biological replicate 15 [miRNA] |
| GSM2473901 |
Neutrophils, Patient, JIA, ADM, Biological replicate 16 [miRNA] |
| GSM2473902 |
Neutrophils, Patient, JIA, ADM, Biological replicate 17 [miRNA] |
| GSM2473903 |
Neutrophils, Patient, JIA, ADM, Biological replicate 18 [miRNA] |
| GSM2473904 |
Neutrophils, Patient, JIA, ADM, Biological replicate 19 [miRNA] |
| GSM2473905 |
Neutrophils, Patient, JIA, ADM, Biological replicate 20 [miRNA] |
| GSM2473906 |
Neutrophils, Patient, JIA, ADM, Biological replicate 21 [miRNA] |
| GSM2473907 |
Neutrophils, Patient, JIA, ADM, Biological replicate 22 [miRNA] |
| GSM2473908 |
Neutrophils, Patient, JIA, ADM, Biological replicate 23 [miRNA] |
| GSM2473909 |
Neutrophils, Patient, JIA, ADM, Biological replicate 24 [miRNA] |
| GSM2473910 |
Neutrophils, Patient, JIA, ADM, Biological replicate 25 [miRNA] |
| GSM2473911 |
Neutrophils, Patient, JIA, ADM, Biological replicate 26 [miRNA] |
| GSM2473912 |
Neutrophils, Patient, JIA, ADM, Biological replicate 27 [miRNA] |
| GSM2473913 |
Neutrophils, Patient, JIA, ADM, Biological replicate 28 [miRNA] |
| GSM2473914 |
Neutrophils, Patient, JIA, CRM, Biological replicate 1 [miRNA] |
| GSM2473915 |
Neutrophils, Patient, JIA, CRM, Biological replicate 2 [miRNA] |
| GSM2473916 |
Neutrophils, Patient, JIA, CRM, Biological replicate 3 [miRNA] |
| GSM2473917 |
Neutrophils, Patient, JIA, CRM, Biological replicate 4 [miRNA] |
| GSM2473918 |
Neutrophils, Patient, JIA, CRM, Biological replicate 5 [miRNA] |
| GSM2473919 |
Neutrophils, Patient, JIA, CRM, Biological replicate 6 [miRNA] |
| GSM2473920 |
Neutrophils, Patient, JIA, CRM, Biological replicate 7 [miRNA] |
| GSM2473921 |
Neutrophils, Patient, JIA, CRM, Biological replicate 8 [miRNA] |
| GSM2473922 |
Neutrophils, Patient, JIA, CRM, Biological replicate 9 [miRNA] |
| GSM2473923 |
Neutrophils, Patient, JIA, CRM, Biological replicate 10 [miRNA] |
| GSM2473924 |
Neutrophils, Patient, JIA, CRM, Biological replicate 11 [miRNA] |
| GSM2473925 |
Neutrophils, Patient, JIA, CRM, Biological replicate 12 [miRNA] |
| GSM2473926 |
Neutrophils, Patient, JIA, CRM, Biological replicate 13 [miRNA] |
| GSM2473927 |
Neutrophils, Patient, JIA, CRM, Biological replicate 14 [miRNA] |
| GSM2473928 |
Neutrophils, Patient, JIA, CRM, Biological replicate 15 [miRNA] |
| GSM2473929 |
Neutrophils, Patient, JIA, CRM, Biological replicate 16 [miRNA] |
| GSM2473930 |
Neutrophils, Patient, JIA, CRM, Biological replicate 17 [miRNA] |
| GSM2473931 |
Neutrophils, Patient, JIA, CRM, Biological replicate 18 [miRNA] |
| GSM2473932 |
Neutrophils, Patient, JIA, CRM, Biological replicate 19 [miRNA] |
| GSM2473933 |
Neutrophils, Patient, JIA, CRM, Biological replicate 20 [miRNA] |
| GSM2473934 |
Neutrophils, Patient, JIA, CRM, Biological replicate 21 [miRNA] |
| GSM2473935 |
Neutrophils, Patient, JIA, CRM, Biological replicate 22 [miRNA] |
| GSM2473936 |
Neutrophils, Patient, JIA, CRM, Biological replicate 23 [miRNA] |
| GSM2473937 |
Neutrophils, Patient, JIA, CRM, Biological replicate 24 [miRNA] |
| GSM2473938 |
Neutrophils, Patient, JIA, CRM, Biological replicate 25 [miRNA] |
| GSM2473939 |
Neutrophils, Patient, JIA, CRM, Biological replicate 26 [miRNA] |
| GSM2473940 |
Neutrophils, Patient, JIA, CRM, Biological replicate 27 [miRNA] |
| GSM2473941 |
Neutrophils, Patient, JIA, CRM, Biological replicate 28 [miRNA] |
| GSM2473942 |
Neutrophils, Patient, JIA, CRM, Biological replicate 29 [miRNA] |
| GSM2473943 |
Neutrophils, Patient, JIA, CRM, Biological replicate 30 [miRNA] |
| GSM2473944 |
Neutrophils, Patient, JIA, CRM, Biological replicate 31 [miRNA] |
| GSM2473945 |
Neutrophils, Patient, JIA, CRM, Biological replicate 32 [miRNA] |
| GSM2473946 |
Neutrophils, Patient, JIA, ID, Biological replicate 1 [miRNA] |
| GSM2473947 |
Neutrophils, Patient, JIA, ID, Biological replicate 2 [miRNA] |
| GSM2473948 |
Neutrophils, Patient, JIA, ID, Biological replicate 3 [miRNA] |
| GSM2473949 |
Neutrophils, Patient, JIA, ID, Biological replicate 4 [miRNA] |
| GSM2473950 |
Neutrophils, Patient, JIA, ID, Biological replicate 5 [miRNA] |
| GSM2473951 |
Neutrophils, Patient, JIA, ID, Biological replicate 6 [miRNA] |
| GSM2473952 |
Neutrophils, Patient, JIA, ID, Biological replicate 7 [miRNA] |
| GSM2473953 |
Neutrophils, Patient, JIA, ID, Biological replicate 8 [miRNA] |
| GSM2473954 |
Neutrophils, Patient, JIA, ID, Biological replicate 9 [miRNA] |
| GSM2473955 |
Neutrophils, Patient, JIA, ID, Biological replicate 10 [miRNA] |
| GSM2473956 |
Neutrophils, Patient, JIA, ID, Biological replicate 11 [miRNA] |
| GSM2473957 |
Neutrophils, Patient, JIA, ID, Biological replicate 12 [miRNA] |
| GSM2473958 |
Neutrophils, Patient, JIA, ID, Biological replicate 13 [miRNA] |
| GSM2473959 |
Neutrophils, Patient, JIA, ID, Biological replicate 14 [miRNA] |
| GSM2473960 |
Neutrophils, Patient, JIA, ID, Biological replicate 15 [miRNA] |
| GSM2473961 |
Neutrophils, Patient, JIA, ID, Biological replicate 16 [miRNA] |
| GSM2473962 |
Neutrophils, Patient, JIA, ID, Biological replicate 17 [miRNA] |
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| Relations |
| BioProject |
PRJNA369430 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE94354_RAW.tar |
1.4 Gb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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