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Status |
Public on Feb 18, 2018 |
Title |
Transcriptome profiles of liver biopsy tissues from sever alcoholic hepatitis patients (validation cohort, Brussels) |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Corticosteroids are the current standard of care to improve short_term mortality in severe alcoholic hepatitis (AH), although nearly 40% of the patients do not respond and accurate pre_treatment predictors are lacking. We developed 123_gene prognostic score based on molecular and clinical variables before initiation of corticosteroids. Furthermore, The gene signature was implemented in an FDA_approved platform (NanoString), and verified for technical validity and prognostic capability. Here we demonstrated that a Nanostring_based gene expressoin risk classificatoin is useful to predict mortality in patients with severe alcoholic hepatitis who were treated by corticosteroid
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Overall design |
Gene expression profiling of formalin-fixed paraffin-embedded liver biopsy tissues obtained at the time of enrollment.
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Contributor(s) |
Trépo E, Goossens N, Fujiwara N, Hoshida Y, Franchimont D |
Citation(s) |
29158192 |
Submission date |
Feb 01, 2017 |
Last update date |
Mar 21, 2019 |
Contact name |
Yujin Hoshida |
E-mail(s) |
Yujin.Hoshida@UTSouthwestern.edu
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Organization name |
University of Texas Southwestern Medical Center
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Street address |
5323 Harry Hines Blvd
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City |
Dallas |
State/province |
TX |
ZIP/Postal code |
75390 |
Country |
USA |
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Platforms (1) |
GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
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Samples (38)
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This SubSeries is part of SuperSeries: |
GSE94417 |
An integrative transcriptomic and clinical score for mortality prediction in severe alcoholic hepatitis treated with corticosteroids |
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Relations |
BioProject |
PRJNA369564 |