|
| Status |
Public on Sep 01, 2019 |
| Title |
Transcriptomics of an in vitro model of sorafenib resistance in Huh7 hepatocellular carcinoma cell line |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Hepatocellular carcinoma (HCC) is often diagnosed in patients with advanced disease who are ineligible for curative surgical therapies. Sorafenib, a multi-kinase inhibitor, is currently the only approved drug used in treating such patients. However, patients rapidly become unresponsive due to inherent and acquired drug resistance. To better understand the molecular mechanisms underlying sorafenib resistance in HCC at a global level in an unbiased manner, we conducted gene expression analysis using in vitro models of HCC sorafenib resistance using the Huh7 cell line, including a resistant pool of cells and a specific clone derived from the resistant pool.
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| |
|
| Overall design |
Untreated parental Huh7 HCC cells (n=3), Sorafenib-resistant pool Huh7 cells (n=3), Sorafenib-resistant clone A7 Huh7 cells (n=3)
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| |
|
| Contributor(s) |
Regan-Fendt KE, Reyes R, Jacob ST, Motiwala T |
| Citation(s) |
32977582 |
| Submission date |
Feb 06, 2017 |
| Last update date |
Nov 02, 2020 |
| Contact name |
Kelly Regan |
| E-mail(s) |
kelly.regan@osumc.edu
|
| Organization name |
The Ohio State Univ
|
| Department |
Biomedical Informatics
|
| Street address |
1800 Cannon Drive
|
| City |
Columbus |
| State/province |
Ohio |
| ZIP/Postal code |
43206 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA371461 |
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