|
| Status |
Public on Sep 06, 2017 |
| Title |
Gene expression changes in primary GBM neurosphere cultures after 24 hours of CDK7 inhibition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
CDK7 controlls both global gene transcription and cell cycle progression. To see what global gene changes were occuring after application of THZ1 to GBM cells, we conducted the following microarray analyses.
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| |
|
| Overall design |
Two distinct GBM neurosphere cell lines were treated in quadruplicate with DMSO vehicle or 200 nM of the irreversible CDK7 inhibitor THZ1. After 24 hours, total RNA was harvested from the samples and hybridised to the arrays.
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| |
|
| Contributor(s) |
Greenall S, Johns T |
| Citation(s) |
28504693 |
| Submission date |
Feb 15, 2017 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Sam Greenall |
| E-mail(s) |
sameer.greenall@hudson.org.au
|
| Organization name |
Hudson Institute of Medical Research
|
| Department |
Centre for Cancer Research
|
| Lab |
Oncogenic Signalling Laboratory
|
| Street address |
27-31 Wright Street
|
| City |
Clayton |
| State/province |
VIC |
| ZIP/Postal code |
3168 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
|
| Samples (16)
|
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| Relations |
| BioProject |
PRJNA374870 |
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