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| Status |
Public on Jun 28, 2017 |
| Title |
Dynamic and stable enhancer-promoter contacts regulate terminal differentiation [UMI-4C] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
Genome-wide chromosome conformation capture (Hi-C) and promoter-capture Hi-C (CHi-C) were performed during epidermal differentiation. These data indicate that dynamic and constitutive enhancer-promoter contacts combine to control gene induction during differentiation and that chromosome conformation enables discovery of new TFs with distinct roles in this process.
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| |
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| Overall design |
Hi-C and CHi-C data from epidermal keratinocyte progenitor and differentiated cells.
|
| |
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| Contributor(s) |
Rubin AJ, Barajas B, Khavari PA |
| Citation(s) |
28805829 |
| Submission date |
Feb 20, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Paul Khavari |
| Organization name |
Stanford University
|
| Street address |
269 Campus Drive, CCSR 2150
|
| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (10)
|
| GSM2496143 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 1 - Differentiation Day 0 - Control siRNA |
| GSM2496144 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 2 - Differentiation Day 0 - Control siRNA |
| GSM2496145 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 1 - Differentiation Day 3 - Control siRNA |
| GSM2496146 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 2 - Differentiation Day 3 - Control siRNA |
| GSM2496147 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 1 - Differentiation Day 3 - KLF4 siRNA |
| GSM2496148 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 2 - Differentiation Day 3 - KLF4 siRNA |
| GSM2496149 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 1 - Differentiation Day 3 - ZNF750 siRNA |
| GSM2496150 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 2 - Differentiation Day 3 - ZNF750 siRNA |
| GSM2496151 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 1 - Differentiation Day 3 - EHF siRNA |
| GSM2496152 |
UMI-4C Primary Epidermal Keratinocyte Biological Replicate 2 - Differentiation Day 3 - EHF siRNA |
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| This SubSeries is part of SuperSeries: |
| GSE84662 |
Dynamic and stable enhancer-promoter contacts regulate terminal differentiation |
|
| Relations |
| BioProject |
PRJNA376091 |
| SRA |
SRP100408 |
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