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Series GSE9537 Query DataSets for GSE9537
Status Public on Mar 28, 2008
Title Microarray analysis of perichondral and reserve growth plate zones
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary In the growth plate, the reserve and perichondral zones have been hypothesized to have similar functions, but their exact functions are poorly understood. Our hypothesis was that significant differential gene expression exists between perichondral and reserve chondrocytes that may differentiate the respective functions of these two zones. Normal Sprague-Dawley rat growth plate chondrocytes from the perichondral zone (PC), reserve zone (RZ), proliferative zone (PZ), and hypertrophic zone (HZ) were isolated by laser microdissection and then subjected to microarray analysis. In order to most comprehensively capture the unique features of the two zones, we analyzed both the most highly expressed genes and those that were most significantly different from the proliferative zone (PZ) as a single comparator.
Keywords: cell specific expression profiles
 
Overall design 2 microarray replicates were obtained for each zone, using pooled quantities of RNA from 3 rats each at 42 and 46 days of age.
 
Contributor(s) Zhang M, Pritchard MR, Middleton FA, Horton JA, Damron TA
Citation(s) 18579462, 19480974, 20616531
Submission date Nov 06, 2007
Last update date Nov 08, 2019
Contact name Frank A Middleton
E-mail(s) middletf@upstate.edu
Phone 315-464-7721
Organization name SUNY Upstate Medical Univ
Department Neuroscience and Physiology
Street address 750 East Adams St
City Syracuse
State/province NY
ZIP/Postal code 13210
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (8)
GSM241444 RatFemur_HypertrophicZone_42d
GSM241445 RatFemur_HypertrophicZone_46d
GSM241446 RatFemur_PerichondralZone_42d
Relations
BioProject PRJNA103349

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE9537_RAW.tar 17.3 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Raw data provided as supplementary file

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