|
| Status |
Public on May 08, 2018 |
| Title |
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed high-throughput sequencing of chromatin-associated RNA from CH12 cells depleted of Ddx1 and induced to undergo Class Switch Recombination (CSR).
|
| |
|
| Overall design |
CH12 cells depleted for Ddx1 (shDdx1) and control (shCtrl), cultured in unstimulated (UNS) and CSR inducing (CIT) conditions; 2 replicates each sample.
|
| |
|
| Contributor(s) |
Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 02, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Nicholas Proudfoot |
| E-mail(s) |
nicholas.proudfoot@path.ox.ac.uk
|
| Organization name |
Sir William Dunn School of Pathology, University of Oxford
|
| Street address |
South Parks Road
|
| City |
Oxford |
| ZIP/Postal code |
OX1 3RE |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA377747 |
| SRA |
SRP101293 |
Less...
More...