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Series GSE9600 Query DataSets for GSE9600
Status Public on Aug 03, 2010
Title Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; cetuximab, a monoclonal antibody (mAb) against Epidermal Growth Factor Receptor (EGFR), and AMG 479, a mAb against Insulin-like Growth Factor-1 Receptor (IGF-1R).
In tumor tissue of this patient we observed gene expression modulation by cetuximab and AMG 479 suggesting crosstalk between the EGFR and IGF-1R pathways that may have sensitized the tumor to MTX. This represents a promising novel approach to development of targeted agents in refractory cancer.
Keywords: tumor response
 
Overall design 10 samples from different time points during course of treatment in a single individual.
 
Contributor(s) Chung CH, Parker JS, Murphy B
Citation(s) 20652976
Submission date Nov 14, 2007
Last update date Mar 25, 2019
Contact name Christine H. Chung
E-mail(s) christine.chung@vanderbilt.edu
Phone 615-322-4967
Fax 615343-7602
Organization name Vanderbilt University
Department Internal Medicine
Lab Chung
Street address 777 PRB
City Nashville
State/province TN
ZIP/Postal code 37232-6307
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (10)
GSM242881 1352FFPE_NL1
GSM242882 1352FFPE_NL2
GSM242883 1352FFPE_T1A
Relations
BioProject PRJNA103447

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE9600_RAW.tar 41.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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