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Status |
Public on Aug 03, 2010 |
Title |
Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; cetuximab, a monoclonal antibody (mAb) against Epidermal Growth Factor Receptor (EGFR), and AMG 479, a mAb against Insulin-like Growth Factor-1 Receptor (IGF-1R). In tumor tissue of this patient we observed gene expression modulation by cetuximab and AMG 479 suggesting crosstalk between the EGFR and IGF-1R pathways that may have sensitized the tumor to MTX. This represents a promising novel approach to development of targeted agents in refractory cancer. Keywords: tumor response
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Overall design |
10 samples from different time points during course of treatment in a single individual.
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Contributor(s) |
Chung CH, Parker JS, Murphy B |
Citation(s) |
20652976 |
Submission date |
Nov 14, 2007 |
Last update date |
Mar 25, 2019 |
Contact name |
Christine H. Chung |
E-mail(s) |
christine.chung@vanderbilt.edu
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Phone |
615-322-4967
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Fax |
615343-7602
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Organization name |
Vanderbilt University
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Department |
Internal Medicine
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Lab |
Chung
|
Street address |
777 PRB
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City |
Nashville |
State/province |
TN |
ZIP/Postal code |
37232-6307 |
Country |
USA |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (10)
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Relations |
BioProject |
PRJNA103447 |