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| Status |
Public on Dec 09, 2008 |
| Title |
Lungs of ferrets infected with either an H3N2 or H5N1 subtype of influenza A virus. |
| Platform organism |
Canis lupus familiaris |
| Sample organism |
Mustela putorius furo |
| Experiment type |
Expression profiling by array
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| Summary |
A global genomics approach was used to identify patterns of immune dysregulation during H5N1 influenza virus infection as the host response, in particular hyperchemokinemia, is thought to contribute to the extreme pathology associated with this disease.
Keywords: time course
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| Overall design |
Ferrets were inoculated intranasally with 10(6) EID50 of either A/Vietnam/1203/04 (H5N1) or A/Panama/2007/99 (H3N2). At 2, 4 and 6 days post-infection (DPI), ferrets were euthanized and lung tissue was excised for RNA purification and subsequent gene expression analysis.
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| Contributor(s) |
Kelvin DJ |
| Citation(s) |
18684821 |
| Submission date |
Nov 14, 2007 |
| Last update date |
Mar 17, 2012 |
| Contact name |
Longsi Ran |
| E-mail(s) |
lran@uhnresearch.ca
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| Phone |
416-581-7607
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| Organization name |
Toronto General Research Institute
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| Department |
Division of Experimental Therapeutics
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| Lab |
Dr. David J Kelvin
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| Street address |
101 College Street
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| City |
Toronto |
| State/province |
ON |
| ZIP/Postal code |
M5G 1L7 |
| Country |
Canada |
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| Platforms (1) |
| GPL3738 |
[Canine_2] Affymetrix Canine Genome 2.0 Array |
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| Samples (23)
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| GSM242965 |
Ferret lung with H3N2 at Day 0, biological rep1 |
| GSM242966 |
Ferret lung with H3N2 at Day 0, biological rep2 |
| GSM242967 |
Ferret lung with H3N2 at Day 0, biological rep3 |
| GSM242968 |
Ferret lung with H3N2 at Day 2, biological rep1 |
| GSM242969 |
Ferret lung with H3N2 at Day 2, biological rep2 |
| GSM242970 |
Ferret lung with H3N2 at Day 2, biological rep3 |
| GSM242971 |
Ferret lung with H3N2 at Day 4, biological rep1 |
| GSM242972 |
Ferret lung with H3N2 at Day 4, biological rep2 |
| GSM242973 |
Ferret lung with H3N2 at Day 6, biological rep1 |
| GSM242974 |
Ferret lung with H3N2 at Day 6, biological rep2 |
| GSM242975 |
Ferret lung with H3N2 at Day 6, biological rep3 |
| GSM242976 |
Ferret lung with H5N1 at Day 0, biological rep1 |
| GSM242977 |
Ferret lung with H5N1 at Day 0, biological rep2 |
| GSM242978 |
Ferret lung with H5N1 at Day 0, biological rep3 |
| GSM242979 |
Ferret lung with H5N1 at Day 2, biological rep1 |
| GSM242980 |
Ferret lung with H5N1 at Day 2, biological rep2 |
| GSM242981 |
Ferret lung with H5N1 at Day 2, biological rep3 |
| GSM242982 |
Ferret lung with H5N1 at Day 4, biological rep1 |
| GSM242983 |
Ferret lung with H5N1 at Day 4, biological rep2 |
| GSM242984 |
Ferret lung with H5N1 at Day 4, biological rep3 |
| GSM242985 |
Ferret lung with H5N1 at Day 6, biological rep1 |
| GSM242986 |
Ferret lung with H5N1 at Day 6, biological rep2 |
| GSM242987 |
Ferret lung with H5N1 at Day 6, biological rep3 |
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| Relations |
| BioProject |
PRJNA103455 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE9606_RAW.tar |
81.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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