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| Status |
Public on Mar 11, 2017 |
| Title |
The Quantitative Analysis of Transcriptomes Derived From Ezh2- or Ezh1/2-Deleted Leukemia Stem Cells of Murine Acute Myloid Leukemia |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report dual genetic delstion of Ezh1/2 in murine AML model induced cell cyle progression of quiescent LSCs and cell differentiation of LSCs. To investigate the underlying mechanism by which Ezh1/2 regulate quiescent LSCs and maintein the stemness of LSCs, we performed RNA sequencing of L-GMPs derived from Ezh2- and Ezh1/2-deleted AML mice.
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| Overall design |
Examination and comprison of transcriptomes from c-kit+ AML cells with 4 types of genetic backgraound; Ezh1 +/+ Ezh2 flox/flox, Ezh1+/+ Ezh2 Δ/Δ, Ezh1 -/- Ezh2 flox/flox and Ezh1-/- Ezh2 Δ/Δ.
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| Contributor(s) |
Fujita S, Kitabayashi I |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 10, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Shuhei Fujita |
| E-mail(s) |
shfujita@ncc.go.jp
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| Phone |
+81-3-3542-2511
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| Organization name |
National Cancer Center
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| Department |
Division of Hematological Malignancy
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| Street address |
5-1-1 Tsukiji, Chuo-ku
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| City |
Tokyo |
| ZIP/Postal code |
104-0045 |
| Country |
Japan |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA378715 |
| SRA |
SRP101698 |
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