To identify genes whose expression is under the strict dependence of hepatocyte PPARa activity, we used a mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to their liver WT littermates (albumin-Cre-/- Pparaflox/flox or LWT) fed ad libitum or fasted for 24 hours.
Overall design
There are 24 liver samples, each from an individual mouse. The samples are from Ppara liver KO (LKO) and liver WT (LWT) male mice of 8 week-old from the same genetic background (C57Bl/6J) fed ad libitum or fasted for 24 hours (n=6 mice/genotype/group). All mice were sacrified at ZT16.
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