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| Status |
Public on Mar 14, 2018 |
| Title |
Transcriptome profiling of FK866 response in CCRF-CEM parental and resistant cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Parental and resistant CCRF-CEM cells were treated for 48 hr with a sublethal dose of FK866 (5 nM) or DMSO (Mock, control treatment). This comparison enables the identification of the specific transcriptional alterations induced by FK866 in parental or resistant cells.
Keywords: transcriptome profiling, FK866, drug resistance
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| Overall design |
Gene expression signals derived from parental and resistant CCRF-CEM cells after FK866 treatment were compared by microarrays analysis. Total RNA were isolated from CCRF-CEM cells treated with FK866 5 nM or DMSO (mock, control treatment) for 48 hr. Cells lysates were collected from control cells (mock) and from treated cells (FK866). All experiments were run with biological replicates.
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| Contributor(s) |
Tebaldi T, Zucal C, D'Agostino VG, Thongon N, Adami V, Provenzani A |
| Citation(s) |
29541451 |
| Submission date |
Mar 15, 2017 |
| Last update date |
Mar 26, 2018 |
| Contact name |
Toma Tebaldi |
| E-mail(s) |
t.tebaldi@unitn.it
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| Organization name |
University of Trento
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| Department |
Centre for Integrative Biology
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| Street address |
via Sommarive n. 9
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| City |
Povo |
| State/province |
Trento |
| ZIP/Postal code |
38123 |
| Country |
Italy |
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| Platforms (1) |
| GPL13497 |
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (13)
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| GSM2536958 |
parental CCRF-CEM, FK866 treated, total RNA, bio_rep_1 |
| GSM2536959 |
parental CCRF-CEM, FK866 treated, total RNA, bio_rep_2 |
| GSM2536960 |
parental CCRF-CEM, mock, total RNA, bio_rep_1 |
| GSM2536961 |
parental CCRF-CEM, mock, total RNA, bio_rep_2 |
| GSM2536962 |
parental CCRF-CEM, mock, total RNA, bio_rep_3 |
| GSM2536963 |
resistant CCRF-CEM, FK866 treated, total RNA, bio_rep_1 |
| GSM2536964 |
resistant CCRF-CEM, FK866 treated, total RNA, bio_rep_2 |
| GSM2536965 |
resistant CCRF-CEM, FK866 treated, total RNA, bio_rep_3 |
| GSM2536966 |
resistant CCRF-CEM, FK866 treated, total RNA, bio_rep_4 |
| GSM2536967 |
resistant CCRF-CEM, mock, total RNA, bio_rep_1 |
| GSM2536968 |
resistant CCRF-CEM, mock, total RNA, bio_rep_2 |
| GSM2536969 |
resistant CCRF-CEM, mock, total RNA, bio_rep_3 |
| GSM2536970 |
resistant CCRF-CEM, mock, total RNA, bio_rep_4 |
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| Relations |
| BioProject |
PRJNA379272 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE96636_RAW.tar |
116.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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