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| Status |
Public on Sep 28, 2017 |
| Title |
Widespread activation of antisense transcription of the host genome during Herpes simplex virus 1 infection |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Third-party reanalysis
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| Summary |
We show that Herpes simplex virus 1 (HSV-1) induces the expression of about 1000 antisense transcripts from the human host cell genome.
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| Overall design |
Human WI-38 and HeLa cells were infected with Herpes simplex virus 1, and antisense transcripts on the host cell genome defined using a custom algorithm.
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| Contributor(s) |
Wyler E, Menegatti J, Franke V, Kocks C, Boltengagen A, Theil K, Hennig T, Ferrai C, Rutkowski A, Baer L, Kermas L, Friedel CC, Rajewsky N, Akalin A, Dölken L, Grässer F, Landthaler M |
| Citation(s) |
29089033 |
| Submission date |
Mar 24, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Emanuel Wyler |
| E-mail(s) |
emanuel.wyler@mdc-berlin.de
|
| Phone |
+49 30 9406 3009
|
| Organization name |
Max Delbrück Center for Molecular Medicine
|
| Department |
Berlin Institute for Medical Systems Biology
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| Lab |
RNA Biology and Posttranscriptional Regulation
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| Street address |
Robert Roessle Str 10
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| City |
Berlin |
| ZIP/Postal code |
13125 |
| Country |
Germany |
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| Platforms (3) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (58)
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| GSM2549749 |
WI-38 cells, stranded polyA RNA-seq, uninfected, Replicate 1 |
| GSM2549750 |
WI-38 cells, stranded polyA RNA-seq, uninfected, Replicate 2 |
| GSM2549751 |
WI-38 cells, stranded polyA RNA-seq, 4h HSV-1 infection, Replicate 1 |
| GSM2549752 |
WI-38 cells, stranded polyA RNA-seq, 4h HSV-1 infection, Replicate 2 |
| GSM2549753 |
WI-38 cells, stranded polyA RNA-seq, 9h HSV-1 infection, Replicate 1 |
| GSM2549754 |
WI-38 cells, stranded polyA RNA-seq, 9h HSV-1 infection, Replicate 2 |
| GSM2549755 |
WI-38 cells, stranded polyA RNA-seq, 15h HSV-1 infection, Replicate 1 |
| GSM2549756 |
WI-38 cells, stranded polyA RNA-seq, 15h HSV-1 infection, Replicate 2 |
| GSM2549757 |
WI-38 cells, unstranded polyA RNA-seq, uninfected, Replicate 1, total RNA |
| GSM2549758 |
WI-38 cells, unstranded polyA RNA-seq, uninfected, Replicate 2, total RNA |
| GSM2549759 |
WI-38 cells, unstranded polyA RNA-seq, 4h HSV-1 infection, Replicate 1, total RNA |
| GSM2549760 |
WI-38 cells, unstranded polyA RNA-seq, 4h HSV-1 infection, Replicate 2, total RNA |
| GSM2549761 |
WI-38 cells, unstranded polyA RNA-seq, 9h HSV-1 infection, Replicate 1, total RNA |
| GSM2549762 |
WI-38 cells, unstranded polyA RNA-seq, 9h HSV-1 infection, Replicate 2, total RNA |
| GSM2549763 |
WI-38 cells, unstranded polyA RNA-seq, 15h HSV-1 infection, Replicate 1, total RNA |
| GSM2549764 |
WI-38 cells, unstranded polyA RNA-seq, 15h HSV-1 infection, Replicate 2, total RNA |
| GSM2549765 |
WI-38 cells, unstranded polyA RNA-seq, uninfected, Replicate 1, labeled RNA |
| GSM2549766 |
WI-38 cells, unstranded polyA RNA-seq, uninfected, Replicate 2, labeled RNA |
| GSM2549767 |
WI-38 cells, unstranded polyA RNA-seq, 4h HSV-1 infection, Replicate 1, labeled RNA |
| GSM2549768 |
WI-38 cells, unstranded polyA RNA-seq, 4h HSV-1 infection, Replicate 2, labeled RNA |
| GSM2549769 |
WI-38 cells, unstranded polyA RNA-seq, 9h HSV-1 infection, Replicate 1, labeled RNA |
| GSM2549770 |
WI-38 cells, unstranded polyA RNA-seq, 9h HSV-1 infection, Replicate 2, labeled RNA |
| GSM2549771 |
WI-38 cells, unstranded polyA RNA-seq, 15h HSV-1 infection, Replicate 1, labeled RNA |
| GSM2549772 |
WI-38 cells, unstranded polyA RNA-seq, 15h HSV-1 infection, Replicate 2, labeled RNA |
| GSM2549773 |
WI-38 cells, unstranded polyA RNA-seq, uninfected, Replicate 1, unlabeled RNA |
| GSM2549774 |
WI-38 cells, unstranded polyA RNA-seq, uninfected, Replicate 2, unlabeled RNA |
| GSM2549775 |
WI-38 cells, unstranded polyA RNA-seq, 4h HSV-1 infection, Replicate 1, unlabeled RNA |
| GSM2549776 |
WI-38 cells, unstranded polyA RNA-seq, 4h HSV-1 infection, Replicate 2, unlabeled RNA |
| GSM2549777 |
WI-38 cells, unstranded polyA RNA-seq, 9h HSV-1 infection, Replicate 1, unlabeled RNA |
| GSM2549778 |
WI-38 cells, unstranded polyA RNA-seq, 9h HSV-1 infection, Replicate 2, unlabeled RNA |
| GSM2549779 |
WI-38 cells, unstranded polyA RNA-seq, 15h HSV-1 infection, Replicate 1, unlabeled RNA |
| GSM2549780 |
WI-38 cells, unstranded polyA RNA-seq, 15h HSV-1 infection, Replicate 2, unlabeled RNA |
| GSM2787804 |
HeLa cells, stranded RiboZero RNA-seq, EYFP overexpression |
| GSM2787805 |
HeLa cells, stranded RiboZero RNA-seq, EYFP-ICP4 overexpression |
| GSM2787806 |
HeLa cells, stranded polyA RNA-seq, uninfected, Replicate 1 |
| GSM2787807 |
HeLa cells, stranded polyA RNA-seq, uninfected, Replicate 2 |
| GSM2787808 |
HeLa cells, stranded polyA RNA-seq, 2h HSV-1 infection, Replicate 1 |
| GSM2787809 |
HeLa cells, stranded polyA RNA-seq, 2h HSV-1 infection, Replicate 2 |
| GSM2787810 |
HeLa cells, stranded polyA RNA-seq, 4h HSV-1 infection, Replicate 1 |
| GSM2787811 |
HeLa cells, stranded polyA RNA-seq, 4h HSV-1 infection, Replicate 2 |
| GSM2787812 |
HeLa cells, stranded polyA RNA-seq, 6h HSV-1 infection, Replicate 1 |
| GSM2787813 |
HeLa cells, stranded polyA RNA-seq, 6h HSV-1 infection, Replicate 2 |
| GSM2787814 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, uninfected, Replicate 1 |
| GSM2787815 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, uninfected, Replicate 2 |
| GSM2787816 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, 2h HSV-1 infection, Replicate 1 |
| GSM2787817 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, 2h HSV-1 infection, Replicate 2 |
| GSM2787818 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, 4h HSV-1 infection, Replicate 1 |
| GSM2787819 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, 4h HSV-1 infection, Replicate 2 |
| GSM2787820 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, 6h HSV-1 infection, Replicate 1 |
| GSM2787821 |
HeLa koBBC3as 56D2 cells, stranded polyA RNA-seq, 6h HSV-1 infection, Replicate 2 |
| GSM2787822 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, uninfected, Replicate 1 |
| GSM2787823 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, uninfected, Replicate 2 |
| GSM2787824 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, 2h uninfected, Replicate 1 |
| GSM2787825 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, 2h uninfected, Replicate 2 |
| GSM2787826 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, 4h uninfected, Replicate 1 |
| GSM2787827 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, 4h uninfected, Replicate 2 |
| GSM2787828 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, 6h uninfected, Replicate 1 |
| GSM2787829 |
HeLa koBBC3as 59F8 cells, stranded polyA RNA-seq, 6h uninfected, Replicate 2 |
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| Relations |
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GSM1444192 |
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GSM1444193 |
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GSM1444166 |
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GSM1444180 |
| Reanalysis of |
GSM1444167 |
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GSM1444181 |
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GSM1444168 |
| Reanalysis of |
GSM1444182 |
| Reanalysis of |
GSM1444169 |
| Reanalysis of |
GSM1444183 |
| Reanalysis of |
GSM1444170 |
| Reanalysis of |
GSM1444184 |
| Reanalysis of |
GSM1712278 |
| Reanalysis of |
GSM1712281 |
| Reanalysis of |
GSM1712282 |
| Reanalysis of |
GSM1712283 |
| Reanalysis of |
GSM1712284 |
| Reanalysis of |
GSM2357382 |
| Reanalysis of |
GSM2241322 |
| Reanalysis of |
GSM2357383 |
| Reanalysis of |
GSM2241321 |
| Reanalysis of |
GSM2357384 |
| BioProject |
PRJNA380401 |
| SRA |
SRP102444 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE97009_HSV1_antisensetranscripts.tsv.gz |
410.1 Kb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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