|
| Status |
Public on Aug 18, 2017 |
| Title |
Effect of selective glucocorticoid receptor modulation (SGRM) on gene expression in human prostate cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Human prostate cancer cell lines treated with androgen receptor (AR) agonists/antagonists and concurrent glucocorticoid receptor (GR) agonist/antagonists
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| |
|
| Overall design |
Human prostate cancer cell lines in charcoal-stripped FCS-containing media were treated for 3 days with AR agonists (R1881 1nM) +/-antagonist (enzalutamide 10uM) and then pulsed with 2 or 6 hour treatment with GR agonist (Dex 100nM) +/- antagonist (SGRM, 335 1uM and 297 1uM) after which RNA was collected and sequenced
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| |
|
| Contributor(s) |
Szmulewitz RZ, Conzen SD, Vander Griend D |
| Citation(s) |
28428441, 38030378 |
| Submission date |
Mar 29, 2017 |
| Last update date |
Apr 17, 2024 |
| Contact name |
WEN-CHING CHAN |
| E-mail(s) |
wenching.chan@gmail.com
|
| Organization name |
The University of Chicago
|
| Department |
Biological Sciences Division
|
| Lab |
Bioinformatics Core
|
| Street address |
900 E. 57th St.
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA380950 |
| SRA |
SRP102707 |
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