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| Status |
Public on Dec 31, 2017 |
| Title |
YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We aimed to clarify the function of YBX2, a germ cell-specific Y-box-binding protein, in endometrial cancer stem cells. Our data demonstrated that expression of YBX2 was essential for a stem cell-like phenotype of endometrial cancer cells. We analyzed enhanced gene expression of IK cells that overexpressed YBX2 (IK-YBX2 cells) by introduction of YBX2 using microarray analysis. The CT45A5 gene was the most upregulated in IK-YBX2 cells, compared with mock cells. Therefore, we focused on CT45A5, which is considered a stemness factor.
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| Overall design |
We analyzed enhanced gene expression of IK-YBX2 cells and mock cells by introduction of YBX2. Microarray analysis was performed by CERI customer service (Saitama, Japan) in accordance with the instructions for One-Color Microarray-Based Gene Expression Analysis, ver 6.0.
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| Contributor(s) |
Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Itakura A, Takeda S, Kato K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 07, 2017 |
| Last update date |
Mar 11, 2021 |
| Contact name |
Izumi Suzuki |
| E-mail(s) |
iyamada@juntendo.ac.jp
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| Phone |
81-90-60353630
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| Organization name |
Juntendo University
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| Street address |
2-1-1 Hongo Bunkyo-ku
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| City |
Tokyo |
| State/province |
東京都 |
| ZIP/Postal code |
113-8421 |
| Country |
Japan |
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| Platforms (1) |
| GPL13497 |
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA382147 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE97511_RAW.tar |
8.6 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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