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| Status |
Public on Apr 11, 2017 |
| Title |
Disrupted miRNA expression in HAND |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
The role of miRNA disregulation in the development of HIV associated Neurocognitive Disorder was assessed in post mortem cerebral tissue.
We used microarrays to compare the expression of miRNAs in patient with HIV showing no neurological complications to those with HAND in the presence or absence of active HIV encephalitis
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| |
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| Overall design |
30 post mortem human neocortex specimens were obtained from the NNTC, several of which had previously been examined using mRNA arrays, and total RNA was extracted, labelled and hybridized to Affymetrix miRNA 3.0 chips to assess specific changes in miRNA expression to provide clues to host genes with altered regulation in HAND.
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| Contributor(s) |
Xu Z, Asahchop EL, Branton WG, Gelman BB, Power CN, Hobman TC |
| Citation(s) |
28594894 |
| Submission date |
Apr 10, 2017 |
| Last update date |
Jul 27, 2018 |
| Contact name |
William George Branton |
| E-mail(s) |
wbranton@ualberta.ca
|
| Phone |
780-492-2148
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| Organization name |
University of Alberta
|
| Department |
Medicine
|
| Lab |
Dr. C. Power
|
| Street address |
611 HMRC University of Alberta
|
| City |
Edmonton |
| State/province |
Alberta |
| ZIP/Postal code |
T6G2S2 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL16384 |
[miRNA-3] Affymetrix Multispecies miRNA-3 Array |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA382423 |
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