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Series GSE98070 Query DataSets for GSE98070
Status Public on Apr 14, 2021
Title MicroRNAs as Regulators of Aging Processes in the Cochlear Lateral Wall of the Mouse Inner Ear (mRNA data set)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Age-related hearing loss (presbycusis) affects more than one-third of Americans over the age of 60, with its prevalence and severity increasing with age. Pathological alterations to the cochlear lateral wall (CLW) disrupting the maintenance of the endocochlear potential (EP) are a major cause of (metabolic) presbycusis. Although molecular mediators of CLW degeneration are largely unknown, several cellular events, including oxidative stress, apoptosis, and inhibition of proliferation, are known to contribute to this dysfunction. Here we have analyzed mRNA and microRNA expression in CLW of young and old mice to profile transcriptional changes that occur as a function of aging. Our results reinforce prior findings about molecular processes and pathways affected by aging and implicate microRNAs that may be involved in influencing these changes.
 
Overall design CBA/CaJ young adult (1-3 months) and aged (1-2.5 years) mice were used in this study. Mice were euthanized and CLWs were micro-dissected from the inner ear. All sample types were prepared in experimental triplicate (n=3).
 
Contributor(s) Lang H, Barth JL
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Submission date Apr 21, 2017
Last update date Jul 25, 2021
Contact name Jeremy Barth
E-mail(s) barthj@musc.edu
Organization name MUSC
Street address 173 Ashley Ave, BSB 627
City Charleston
State/province SC
ZIP/Postal code 29425-5080
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM2586709 CochlearLateralWall_YoungAdult_rep1
GSM2586710 CochlearLateralWall_YoungAdult_rep2
GSM2586711 CochlearLateralWall_YoungAdult_rep3
This SubSeries is part of SuperSeries:
GSE98072 MicroRNAs as Regulators of Aging Processes in the Cochlear Lateral Wall of the Mouse Inner Ear
Relations
BioProject PRJNA383858

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE98070_RAW.tar 22.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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