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| Status |
Public on Oct 13, 2017 |
| Title |
Single-cell RNA-seq reveals differentiation hierarchy of normal human bone marrow and a distinct transcriptome signature of aneuploid cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In order to get a better understanding of the gene signature of aneuploid cells, we applied single cell RNA sequencing on human bone marrow cells from healthy donors and patients with bone marrow failure and cytogenetic abnormalities. We chacterized normal hemaopoiesis as binary differentiation and identified aneuploid cells from patient samples.
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| |
|
| Overall design |
Single Cell RNA-seq
The processed 'normalizedExpression.csv' file includes data for cells which pass the quality controls.
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| |
|
| Contributor(s) |
Zhao X, Gao S |
| Citation(s) |
29030335, 30545929, 33168060 |
| Submission date |
May 19, 2017 |
| Last update date |
Nov 16, 2020 |
| Contact name |
Shouguo Gao |
| E-mail(s) |
gaos2@nih.gov
|
| Phone |
3014029014
|
| Organization name |
National Institutes of Health
|
| Department |
NHLBI
|
| Lab |
Hematology Branch
|
| Street address |
9000 Rockville Pike
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (1202)
|
|
| Relations |
| BioProject |
PRJNA387283 |
| SRA |
SRP107391 |
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