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Series GSE99731 Query DataSets for GSE99731
Status Public on Dec 20, 2017
Title Comprehensive Expression Analysis of microRNAs and mRNAs in Osteoarthritic Synovial Tissue from a Mouse Model of Early Post-Traumatic OA [mRNA]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Our objective was to characterize disease-specific profiles of both microRNAs (miRNAs) and mRNA expression in synovial tissue from a mouse model of early post-traumatic OA to better understand the molecular processes involved in driving OA.
 
Overall design OA was induced in 10-12 week old male C57BL6 mice by bilateral surgical destabilization of the medial meniscus (DMM). RNA was isolated from the anterior region of the synovium of DMM and sham-operated mice at 1 and 6 weeks post-surgery. Expression profiling was performed using Agilent miRNA and mRNA microarrays and validated by qPCR. OA severity was determined histologically in the contralateral joint.
 
Contributor(s) Kung LH, Ravi V, Rowley L, Bell KM, Little CB, Bateman JF
Citation(s) 29255152
Submission date Jun 06, 2017
Last update date Jul 25, 2021
Contact name John Bateman
Organization name Murdoch Childrens Research Institute
Department Skeletal Biology
Lab John Bateman
Street address Flemington Road
City Melbourne
ZIP/Postal code 3052
Country Australia
 
Platforms (1)
GPL21163 Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version]
Samples (16)
GSM2651032 1 wk DMM-1
GSM2651033 1 wk sham-1
GSM2651034 6 wk DMM-1
This SubSeries is part of SuperSeries:
GSE99738 Comprehensive Expression Analysis of microRNAs and mRNAs in Osteoarthritic Synovial Tissue from a Mouse Model of Early Post-Traumatic OA
Relations
BioProject PRJNA389450

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE99731_RAW.tar 211.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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