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| Status |
Public on Dec 19, 2018 |
| Title |
A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients [methylation] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
The Illumina Infinium EPIC Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 867,000 CpGs in ileal fibroblast samples. Samples included 5 control samples and 13 Crohn’s disease samples. The Crohn’s disease samples can be further subdivided into inflamed (2), non-inflamed (7) and stenotic (4) samples.
This experiment together was performed in conjunction with a gene expression experiment (GSE99816). Use Supplemental Table 2 of the manuscript to quickly find the samples that were present in both experiments.
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| Overall design |
Bisulphite converted DNA from 18 samples were hybridised to the Illumina Infinium EPIC Human Methylation Beadchip
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| Contributor(s) |
Li Yim AY, de Bruyn JR, Duijvis NW, Sharp C, Ferrero E, de Jonge WJ, Wildenberg ME, Mannens M, Buskens CJ, D’Haens GR, Henneman P, te Velde AA |
| Citation(s) |
30589872 |
| Submission date |
Jun 07, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Peter Henneman |
| Organization name |
Academic Medical Center Amsterdam
|
| Department |
Clinical Genetics
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| Lab |
Genome Diagnostics
|
| Street address |
Meibergdreef 9
|
| City |
Amsterdam |
| State/province |
Noord Holland |
| ZIP/Postal code |
1105 AZ |
| Country |
Netherlands |
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| Platforms (1) |
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| Samples (18)
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| GSM2652267 |
Fibroblast NINF sample 3 from patient 2 |
| GSM2652268 |
Fibroblast Non_CD sample 4 from patient 3 |
| GSM2652269 |
Fibroblast INF sample 5 from patient 4 |
| GSM2652270 |
Fibroblast Non_CD sample 6 from patient 5 |
| GSM2652271 |
Fibroblast NINF sample 9 from patient 7 |
| GSM2652272 |
Fibroblast INF sample 10 from patient 7 |
| GSM2652273 |
Fibroblast NINF sample 11 from patient 7 |
| GSM2652274 |
Fibroblast NINF sample 13 from patient 7 |
| GSM2652275 |
Fibroblast NINF sample 16 from patient 9 |
| GSM2652276 |
Fibroblast NINF sample 17 from patient 9 |
| GSM2652277 |
Fibroblast NINF sample 21 from patient 11 |
| GSM2652278 |
Fibroblast STEN sample 22 from patient 11 |
| GSM2652279 |
Fibroblast STEN sample 23 from patient 12 |
| GSM2652280 |
Fibroblast STEN sample 24 from patient 12 |
| GSM2652281 |
Fibroblast STEN sample 27 from patient 14 |
| GSM2652282 |
Fibroblast Non_CD sample 28 from patient 15 |
| GSM2652283 |
Fibroblast Non_CD sample 29 from patient 15 |
| GSM2652284 |
Fibroblast Non_CD sample 30 from patient 15 |
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| Relations |
| BioProject |
PRJNA389595 |
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