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| Status |
Public on Feb 14, 2018 |
| Title |
Expression data from 5azaC- or gallic acid-treated human lung cancer H1299 cell line |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gallic acid (also known as 3,4,5-trihydroxybenzoic acid, GA), a naturally occurring phenolic acid, is a major constituent of tea and red wine. It has been demonstrated that GA possess anti-cancer activities. We found the epigenetic effect of GA in tobacco-associated human cancer cell lines.
In this dataset, we include the expression array data from human lung cancer H1299 cell line with or without the treatment of 5azaC or GA. These data were used to obtain genes upregulated in both 5azaC- orGA-treated H1299 cells.
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| Overall design |
In total, 8 samples were analyzed. We generated the following pairwise comparisons using Affymetrix Expression Console™ Software (version 1.4): 5azaC compared with Ctr-Z ; GA compared with Ctrl-G. Genes with a P value < 0.05 and a fold-change ≥2 were selected. To identify the potential epigenetic targets of gallic acid, we performed Venn diagram analysis with genes showing either up-regulated by 5azaC or GA treatment.
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| Contributor(s) |
Lee C, Weng Y |
| Citation(s) |
29416619 |
| Submission date |
Jun 13, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Chia Huei Lee |
| E-mail(s) |
chlee124@nhri.edu.tw
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| Organization name |
Taiwan National Health Research Institute
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| Department |
National Institute of Cancer Research
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| Street address |
35, Keyan Rd.
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| City |
Zhunan Miaoli County |
| ZIP/Postal code |
114 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA390295 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE99993_RAW.tar |
8.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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