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    Kctd3 potassium channel tetramerisation domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 226823, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Kctd3provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 3provided by MGI
    Primary source
    MGI:MGI:2444629
    See related
    Ensembl:ENSMUSG00000026608 AllianceGenome:MGI:2444629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NY-REN-45; 9330185B06; 4930438A20Rik; E330032J19Rik
    Summary
    Predicted to be involved in protein homooligomerization. Located in plasma membrane. Orthologous to human KCTD3 (potassium channel tetramerization domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 20.9), CNS E14 (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kctd3 in Genome Data Viewer
    Location:
    1 H6; 1 93.51 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (188703292..188740095, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (188971095..189007898, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene predicted gene, 25269 Neighboring gene STARR-seq mESC enhancer starr_03379 Neighboring gene STARR-seq mESC enhancer starr_03380 Neighboring gene nuclear encoded tRNA asparagine 3 (anticodon GTT) Neighboring gene STARR-seq mESC enhancer starr_03383 Neighboring gene STARR-seq mESC enhancer starr_03385 Neighboring gene STARR-seq mESC enhancer starr_03387 Neighboring gene STARR-seq mESC enhancer starr_03388 Neighboring gene STARR-seq mESC enhancer starr_03389 Neighboring gene STARR-seq mESC enhancer starr_03390 Neighboring gene STARR-seq mESC enhancer starr_03391 Neighboring gene predicted gene, 36561 Neighboring gene N-acetylneuraminic acid phosphatase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). Cao-Ehlker X, et al. J Biol Chem, 2013 Mar 15. PMID 23382386, Free PMC Article
    2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KCTD3 is an accessory subunit of native HCN3 complexes
      Title: Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359576.1 → NP_001346505.1  BTB/POZ domain-containing protein KCTD3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129312
      Conserved Domains (1) summary
      pfam02214
      Location:20 → 105
      BTB_2; BTB/POZ domain

    2. NM_001359577.1 → NP_001346506.1  BTB/POZ domain-containing protein KCTD3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC129312
      Conserved Domains (1) summary
      pfam02214
      Location:20 → 105
      BTB_2; BTB/POZ domain

    3. NM_001359578.1 → NP_001346507.1  BTB/POZ domain-containing protein KCTD3 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC129312

    4. NM_172650.2 → NP_766238.1  BTB/POZ domain-containing protein KCTD3 isoform 1

      See identical proteins and their annotated locations for NP_766238.1

      Status: VALIDATED

      Source sequence(s)
      AK033491, AK034380, AK087865
      Consensus CDS
      CCDS15608.1
      UniProtKB/Swiss-Prot
      Q6P7X4, Q8BFX3
      Related
      ENSMUSP00000082821.3, ENSMUST00000085678.8
      Conserved Domains (3) summary
      smart00225
      Location:20 → 114
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:20 → 105
      BTB_2; BTB/POZ domain
      cl02567
      Location:246 → 448
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_153196.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129312

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      188703292..188740095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253563.2 → XP_030109423.1  BTB/POZ domain-containing protein KCTD3 isoform X3

    2. XM_036164222.1 → XP_036020115.1  BTB/POZ domain-containing protein KCTD3 isoform X2

    3. XM_036164219.1 → XP_036020112.1  BTB/POZ domain-containing protein KCTD3 isoform X1

      Conserved Domains (1) summary
      cl38908
      Location:21 → 53
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    4. XM_017320182.1 → XP_017175671.1  BTB/POZ domain-containing protein KCTD3 isoform X5

    5. XM_017320175.1 → XP_017175664.1  BTB/POZ domain-containing protein KCTD3 isoform X4

    RNA

    1. XR_001784135.2 RNA Sequence

    2. XR_373771.4 RNA Sequence

    3. XR_001784133.2 RNA Sequence

    4. XR_001784131.2 RNA Sequence

    5. XR_003954946.1 RNA Sequence

      Related
      ENSMUST00000193143.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFX3.1 GenPept UniProtKB/Swiss-Prot:Q8BFX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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