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    Krr1 KRR1, small subunit processome component homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314830, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Krr1provided by RGD
    Official Full Name
    KRR1, small subunit processome component homologprovided by RGD
    Primary source
    RGD:1306183
    See related
    Ensembl:ENSRNOG00000004035 AllianceGenome:RGD:1306183
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hrb2
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in chromosome; intercellular bridge; and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human KRR1 (KRR1 small subunit processome component homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 146.2), Spleen (RPKM 121.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Krr1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (49361794..49374222)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (47475557..47486996)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (54756043..54767477)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351449 Neighboring gene uncharacterized LOC120093587 Neighboring gene uncharacterized LOC108351450 Neighboring gene GLI pathogenesis-related 1 Neighboring gene GLIPR1 like 2 Neighboring gene GLIPR1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KRR1 small subunit processome component homolog
    Names
    HIV-1 Rev binding protein 2
    KRR1, small subunit (SSU) processome component, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108094.2 → NP_001101564.1  KRR1 small subunit processome component homolog

      See identical proteins and their annotated locations for NP_001101564.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128768
      UniProtKB/TrEMBL
      A0A8I6ALQ2, A1A5R3, A6IGI0, F7FJ71
      Related
      ENSRNOP00000059249.1, ENSRNOT00000063917.2
      Conserved Domains (2) summary
      COG1094
      Location:55 → 240
      Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]
      cd22394
      Location:139 → 230
      KH-I_KRR1_rpt2; second type I K homology (KH) RNA-binding domain found in KRR1 small subunit processome component and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      49361794..49374222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079121.2 → XP_038935049.1  KRR1 small subunit processome component homolog isoform X1

      Conserved Domains (2) summary
      cd22394
      Location:42 → 133
      KH-I_KRR1_rpt2; second type I K homology (KH) RNA-binding domain found in KRR1 small subunit processome component and similar proteins
      cl00098
      Location:1 → 38
      KH-I; K homology (KH) RNA-binding domain, type I
    Nucleotide Protein Strain
    Heading Accession and Version

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