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    Rpe ribulose-5-phosphate-3-epimerase [ Mus musculus (house mouse) ]

    Gene ID: 66646, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Rpeprovided by MGI
    Official Full Name
    ribulose-5-phosphate-3-epimeraseprovided by MGI
    Primary source
    MGI:MGI:1913896
    See related
    Ensembl:ENSMUSG00000026005 AllianceGenome:MGI:1913896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810429B02Rik; 5730518J08Rik
    Summary
    Predicted to enable several functions, including monosaccharide binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Predicted to be involved in cellular carbohydrate metabolic process; pentose catabolic process; and pentose-phosphate shunt, non-oxidative branch. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to several human genes including RPE (ribulose-5-phosphate-3-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.6), subcutaneous fat pad adult (RPKM 7.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpe in Genome Data Viewer
    Location:
    1 C3; 1 33.61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66739957..66758964)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66700797..66719805)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene predicted gene, 25411 Neighboring gene STARR-seq mESC enhancer starr_01189 Neighboring gene unc-80, NALCN activator Neighboring gene predicted gene, 39655 Neighboring gene STARR-seq mESC enhancer starr_01190 Neighboring gene STARR-seq mESC enhancer starr_01191 Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene STARR-positive B cell enhancer ABC_E5767 Neighboring gene STARR-positive B cell enhancer ABC_E11073 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:66862655-66862957 Neighboring gene STARR-positive B cell enhancer ABC_E4319 Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5768 Neighboring gene predicted gene 15793 Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Gumaa KA, et al. Biochem J, 1969 Dec. PMID 5360673, Free PMC Article
    2. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Crozet F, et al. Genomics, 1997 Mar 1. PMID 9119401
    3. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article
    4. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
    5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-ribulose-phosphate 3-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-ribulose-phosphate 3-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-ribulose-phosphate 3-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribulose-phosphate 3-epimerase
    Names
    ribulose-5-phosphate-epimerase
    NP_001297571.1
    NP_001297572.1
    NP_001297573.1
    NP_079959.2
    XP_006496251.1
    XP_006496254.1
    XP_030097961.1
    XP_030097980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310642.1 → NP_001297571.1  ribulose-phosphate 3-epimerase isoform 1

      See identical proteins and their annotated locations for NP_001297571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK017774, CK619266, DV651671
      Consensus CDS
      CCDS78602.1
      UniProtKB/TrEMBL
      B2KGF0, Q3UDM8
      Related
      ENSMUSP00000109628.2, ENSMUST00000113995.2
      Conserved Domains (1) summary
      cd00429
      Location:6 → 221
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    2. NM_001310643.1 → NP_001297572.1  ribulose-phosphate 3-epimerase isoform 3

      See identical proteins and their annotated locations for NP_001297572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK017774, CF172967, CK619266
      UniProtKB/Swiss-Prot
      Q8VEE0
      Conserved Domains (1) summary
      cd00429
      Location:1 → 146
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    3. NM_001310644.1 → NP_001297573.1  ribulose-phosphate 3-epimerase isoform 4

      See identical proteins and their annotated locations for NP_001297573.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate 5' exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK017774, AK029088, CK619266
      UniProtKB/TrEMBL
      Q3UDM8
      Conserved Domains (1) summary
      cd00429
      Location:2 → 174
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    4. NM_025683.3 → NP_079959.2  ribulose-phosphate 3-epimerase isoform 2

      See identical proteins and their annotated locations for NP_079959.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end and lacks an alternate 5' exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK017774, CK619266
      Consensus CDS
      CCDS15022.1
      UniProtKB/Swiss-Prot
      Q8C130, Q8VEE0, Q9CQZ3
      UniProtKB/TrEMBL
      Q3UDM8
      Related
      ENSMUSP00000027157.4, ENSMUST00000027157.10
      Conserved Domains (1) summary
      cd00429
      Location:6 → 214
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      66739957..66758964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242120.2 → XP_030097980.1  ribulose-phosphate 3-epimerase isoform X2

      Conserved Domains (1) summary
      cd00429
      Location:1 → 146
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    2. XM_006496188.4 → XP_006496251.1  ribulose-phosphate 3-epimerase isoform X1

      See identical proteins and their annotated locations for XP_006496251.1

      UniProtKB/TrEMBL
      Q3UDM8
      Conserved Domains (1) summary
      cd00429
      Location:6 → 217
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    3. XM_030242101.1 → XP_030097961.1  ribulose-phosphate 3-epimerase isoform X2

      Conserved Domains (1) summary
      cd00429
      Location:1 → 146
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    4. XM_006496191.3 → XP_006496254.1  ribulose-phosphate 3-epimerase isoform X2

      See identical proteins and their annotated locations for XP_006496254.1

      Conserved Domains (1) summary
      cd00429
      Location:1 → 146
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEE0.1 GenPept UniProtKB/Swiss-Prot:Q8VEE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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