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    Prr5l proline rich 5 like [ Mus musculus (house mouse) ]

    Gene ID: 72446, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prr5lprovided by MGI
    Official Full Name
    proline rich 5 likeprovided by MGI
    Primary source
    MGI:MGI:1919696
    See related
    Ensembl:ENSMUSG00000032841 AllianceGenome:MGI:1919696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Protor2; Protor-2; 2600010E01Rik; 4833411O04Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Involved in TORC2 signaling and regulation of fibroblast migration. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase signaling and positive regulation of protein phosphorylation. Located in mitochondrion. Is expressed in cranium; genitourinary system; jaw; and limb. Orthologous to human PRR5L (proline rich 5 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 4.9), cerebellum adult (RPKM 2.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prr5l in Genome Data Viewer
    Location:
    2 E2; 2 53.93 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101543455..101713428, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101713110..101883052, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5948 Neighboring gene predicted gene, 34041 Neighboring gene TNF receptor-associated factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene STARR-seq mESC enhancer starr_05238 Neighboring gene COMM domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101819193-101819405 Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101831937-101832164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101833086-101833410 Neighboring gene predicted gene, 39888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Gan X, et al. Nat Cell Biol, 2012 May 20. PMID 22609986, Free PMC Article
    2. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Pearce LR, et al. Biochem J, 2011 May 15. PMID 21413931
    3. Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Hecht J, et al. Gene Expr Patterns, 2007 Jan. PMID 16829211
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.
      Title: PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    proline-rich protein 5-like
    Names
    protein observed with Rictor-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083810.2 → NP_001077279.1  proline-rich protein 5-like

      See identical proteins and their annotated locations for NP_001077279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL929571, BB166811, BC048394, BY737227, CF171561
      Consensus CDS
      CCDS38186.1
      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Related
      ENSMUSP00000130152.2, ENSMUST00000171088.8
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    2. NM_001110849.1 → NP_001104319.1  proline-rich protein 5-like

      See identical proteins and their annotated locations for NP_001104319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL929571, BB166811, BC048394, CJ073028
      Consensus CDS
      CCDS38186.1
      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Related
      ENSMUSP00000127530.2, ENSMUST00000163762.8
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    3. NM_001355625.1 → NP_001342554.1  proline-rich protein 5-like

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL929534, AL929571
      Consensus CDS
      CCDS38186.1
      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    4. NM_175181.5 → NP_780390.3  proline-rich protein 5-like

      See identical proteins and their annotated locations for NP_780390.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AL929571, BB166811, BC048394, BY737227
      Consensus CDS
      CCDS38186.1
      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Related
      ENSMUSP00000042167.8, ENSMUST00000043845.14
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      101543455..101713428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162597.1 → XP_036018490.1  proline-rich protein 5-like isoform X2

      Conserved Domains (1) summary
      pfam08539
      Location:146 → 265
      HbrB; HbrB-like

    2. XM_036162598.1 → XP_036018491.1  proline-rich protein 5-like isoform X3

      Conserved Domains (1) summary
      pfam08539
      Location:123 → 242
      HbrB; HbrB-like

    3. XM_036162596.1 → XP_036018489.1  proline-rich protein 5-like isoform X2

      Conserved Domains (1) summary
      pfam08539
      Location:146 → 265
      HbrB; HbrB-like

    4. XM_036162599.1 → XP_036018492.1  proline-rich protein 5-like isoform X5

      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    5. XM_017319278.3 → XP_017174767.1  proline-rich protein 5-like isoform X4

      Conserved Domains (1) summary
      pfam08539
      Location:110 → 229
      HbrB; HbrB-like

    6. XM_036162600.1 → XP_036018493.1  proline-rich protein 5-like isoform X5

      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    7. XM_006500236.5 → XP_006500299.2  proline-rich protein 5-like isoform X1

      Conserved Domains (1) summary
      pfam08539
      Location:95 → 214
      HbrB; HbrB-like

    8. XM_006500241.5 → XP_006500304.1  proline-rich protein 5-like isoform X5

      See identical proteins and their annotated locations for XP_006500304.1

      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    9. XM_006500240.5 → XP_006500303.1  proline-rich protein 5-like isoform X5

      See identical proteins and their annotated locations for XP_006500303.1

      UniProtKB/Swiss-Prot
      A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AVJ5.1 GenPept UniProtKB/Swiss-Prot:A2AVJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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