Glrx2 glutaredoxin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glrx2provided by MGI
Official Full Name: glutaredoxin 2provided by MGI
Primary source: MGI:MGI:1916617
See related: Ensembl:ENSMUSG00000018196 AllianceGenome:MGI:1916617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Grx2; 1700010P22Rik
Summary: Enables protein-disulfide reductase activity. Predicted to be involved in response to hydrogen peroxide and response to organic substance. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 6.6), frontal lobe adult (RPKM 6.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 F; 1 62.53 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (143614787..143625416)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (143739224..143749678)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutaredoxin 2 protects lens epithelial cells from epithelial-mesenchymal transition by suppressing mitochondrial oxidative stress-related upregulation of integrin-linked kinase.
Title: Glutaredoxin 2 protects lens epithelial cells from epithelial-mesenchymal transition by suppressing mitochondrial oxidative stress-related upregulation of integrin-linked kinase.
The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.
Title: The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.
Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice.
Title: Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice.
Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3beta.
Title: Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β.
An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet.
Title: An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet.
Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling.
Title: Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling.
Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive.
Title: Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive.
The deleting the Grx2 gene can protect from diet-induced weight gain and the development of obesity-related disorders.
Title: Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle.
ur results demonstrate that the GRX2-mediated regulation of O2(*-)/H2O2 release through the S-glutathionylation of mitochondrial proteins may play an integral role in controlling cellular ROS signaling
Title: Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria.
Grx2 absence impairs mitochondrial fusion, ultrastructure and energetics in primary cardiomyocytes and cardiac tissue.
Title: Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI645710 (e-PCR)
- UniSTS:178447

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH134315 (e-PCR)
- UniSTS:217597

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutaredoxin-2, mitochondrial

Names: thioltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038592.1 → NP_001033681.1 glutaredoxin-2, mitochondrial isoform a

See identical proteins and their annotated locations for NP_001033681.1

Status: VALIDATED

Source sequence(s)

AK005853, AL592403, BY226480

Consensus CDS

CCDS15343.1

UniProtKB/Swiss-Prot

Q923X4, Q9DAG8, Q9JHY6

UniProtKB/TrEMBL

A2A5W4

Related

ENSMUSP00000141022.2, ENSMUST00000185362.7

Conserved Domains (1) summary

cd03419
Location:61 → 142

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
NM_001038593.1 → NP_001033682.1 glutaredoxin-2, mitochondrial isoform b

See identical proteins and their annotated locations for NP_001033682.1

Status: VALIDATED

Source sequence(s)

AK005853, AL592403

Consensus CDS

CCDS15344.1

UniProtKB/TrEMBL

Q3UQ95

Related

ENSMUSP00000121665.2, ENSMUST00000145969.8

Conserved Domains (1) summary

cd03419
Location:28 → 109

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
NM_001038594.1 → NP_001033683.1 glutaredoxin-2, mitochondrial isoform b

See identical proteins and their annotated locations for NP_001033683.1

Status: VALIDATED

Source sequence(s)

AK005853, AK142654, AL592403

Consensus CDS

CCDS15344.1

UniProtKB/TrEMBL

Q3UQ95

Related

ENSMUSP00000121010.2, ENSMUST00000129653.3

Conserved Domains (1) summary

cd03419
Location:28 → 109

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
NM_023505.2 → NP_075994.2 glutaredoxin-2, mitochondrial isoform b

See identical proteins and their annotated locations for NP_075994.2

Status: VALIDATED

Source sequence(s)

AK005853, AL592403

Consensus CDS

CCDS15344.1

UniProtKB/TrEMBL

Q3UQ95

Related

ENSMUSP00000107588.4, ENSMUST00000111957.10

Conserved Domains (1) summary

cd03419
Location:28 → 109

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

143614787..143625416

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529856.3 → XP_006529919.1 glutaredoxin-2, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006529919.1

UniProtKB/TrEMBL

Q3UQ95

Conserved Domains (1) summary

cd03419
Location:28 → 109

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
XM_006529855.5 → XP_006529918.2 glutaredoxin-2, mitochondrial isoform X1
XM_011248068.3 → XP_011246370.1 glutaredoxin-2, mitochondrial isoform X3

Conserved Domains (1) summary

cd03419
Location:19 → 100

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...